Synthesis and evaluation of a technetium-99m labeled cytotoxic bombesin peptide conjugate for targeting bombesin receptor-expressing tumors

Okarvi, Subhani M.; Jammaz, I. Al

doi:10.1016/j.nucmedbio.2009.12.006

Cited by 32 publications

(44 citation statements)

References 34 publications

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“…Meanwhile, mesoporous HA nanoparticles containing 2DG or DOX and also in the combination decreased the cell viability 24 h after the treatments. The results on viability confirmed the previous study on the reducing viability of magnetic mesoporous HA coated by SPIONs nanoparticles, containing DOX and 2DG, on T47D and SKBR3 cell lines [2,10]. The Minor differences with our findings may related to the difference sensitivity of the studied cell lines.…”

Section: Results On Cytotoxic Effects Of the Treatments On Mda-mb-231supporting

confidence: 91%

“…Various targeting ligands have been conjugated to HA nanoparticles, which have shown proper tumor cell targeting and enhanced therapeutic efficacy in vitro. Mesoporous HA has many advantages over other drug delivery Mahdiyeh Shamsi et al, Radiolabeled the nano 2DG/DOX with 99m Tc and tracing in breast cancer cells Original systems including high drug loading capacity, controllable drug release system and co-delivery of two or more drugs and also therapeutic modalities in combination therapy [2,10].…”

Section: Introductionmentioning

confidence: 99%

“…The combination of 2-deoxy-D-glucose (2DG), structural analogue of glucose, and doxorubicin (DOX), a commonly used anticancer chemodrug, have shown a significant cell toxicity on cells with a rapid dividing capacity (T47D) compared to 2DG or DOX alone [11][12][13]. Also it was found that 2DG and DOX loaded with mesoporous HA could enhance the susceptibility of breast cancer cells to chemotherapy and radiotherapy [2,10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A study on drug delivery tracing with radiolabeled mesoporous hydroxyapatite nanoparticles conjugated with 2DG/DOX for breast tumor cells

Shamsi¹,

Zolbanin²,

Moeini³

et al. 2018

Nucl. Med. Rev.

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Section: Results On Cytotoxic Effects Of the Treatments On Mda-mb-231supporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A study on drug delivery tracing with radiolabeled mesoporous hydroxyapatite nanoparticles conjugated with 2DG/DOX for breast tumor cells

Shamsi¹,

Zolbanin²,

Moeini³

et al. 2018

Nucl. Med. Rev.

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show abstract

“…In addition, in vivo the radio-conjugate approach displayed a significant internalization (values ranged between 19-35%) into the tumor cells. The combination of favorable in vitro and in vivo properties may render 99m Tc-MTX-BN as a potential candidate for the targeted imaging and eventually for radionuclide therapy (when labeled with an appropriate radionuclide) [32].…”

Section: Early Detection Of Breast Cancer In Molecular Stagementioning

confidence: 99%

Breast cancer: early diagnosis and effective treatment by drug delivery tracing

Shamsi

Islamian

2017

Nucl. Med. Rev.

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Breast cancer is the most frequent cancer in women and it is the main reason of cancer-related deaths of women worldwide.Different types of breast cancer diagnostic examinations are also available, such as mammography, MRI, biopsy, ultrasound and molecular imaging. Radionuclide-based imaging methods including SPECT and PET are useful in early diagnosis and treatment of the cancer. The radiolabeling of chemo drugs with nanoparticles should be recommended from the standpoint of an early diagnosis and effective treatment of breast cancer.

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“…25,26 The MTX molecule is conjugated to the carrier molecule through the g-carboxylic acid group of the glutamic acid residue to maintain its activity. 27 The a-carboxylic acid of MTX is necessary for binding to DHFR; thus, conjugation via the a-carboxylic acid is not desirable.…”

Section: Methotrexate (Mtx)mentioning

confidence: 99%

Peptide‐mediated targeted drug delivery

Majumdar

Siahaan

2010

Medicinal Research Reviews

130

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Targeted drug delivery to specific group of cells offers an attractive strategy to minimize the undesirable side effects and achieve the therapeutic effect with a lower dose. Both linear and cyclic peptides have been explored as trafficking moiety due to ease of synthesis, structural simplicity, and low probability of undesirable immunogenicity. Peptides derived from sequence of cell surface proteins, such as intercellular adhesion molecule-1 (ICAM-1), LHRH, Bombesin, and LFA-1, have shown potent binding affinity to the target cell surface receptors. Moreover, peptides derived from ICAM-1 receptor can be internalized by the leukemic T-cells along with the conjugated moiety offering the promise to selectively treat cancers and autoimmune diseases. Systematic analyses have revealed that physicochemical properties of the drug-peptide conjugates and their mechanism of receptor-mediated cellular internalization are important controlling factors for developing a successful targeting system. This review is focused on understanding the factors involved in the development of an effective drug-peptide conjugate with an emphasis on the chemistry and biology of the conjugates. Reported results on several promising drug-peptide conjugates have been critically evaluated. The approaches and results presented here will serve as a guide to systematically approach targeted delivery of cytotoxic drug molecules using peptides for treatment of several diseases.

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Synthesis and evaluation of a technetium-99m labeled cytotoxic bombesin peptide conjugate for targeting bombesin receptor-expressing tumors

Cited by 32 publications

References 34 publications

A study on drug delivery tracing with radiolabeled mesoporous hydroxyapatite nanoparticles conjugated with 2DG/DOX for breast tumor cells

A study on drug delivery tracing with radiolabeled mesoporous hydroxyapatite nanoparticles conjugated with 2DG/DOX for breast tumor cells

Breast cancer: early diagnosis and effective treatment by drug delivery tracing

Peptide‐mediated targeted drug delivery

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