Synthesis and evaluation as potential anticancer agents of novel tetracyclic indenoquinoline derivatives

Polycyclization Enabled by Relay Catalysis: One‐Pot Manganese‐Catalyzed C−H Allylation and Silver‐Catalyzed Povarov Reaction

“…[2] Nevertheless, from the viewpoint of sustainableo rg reen chemistry, [3,4] limitations still exist:1 )expensive noble metal based catalysts, such as Pd, Rh, Ru, and Ir,r epresent the majority of catalysts that effect sufficient reactivity;2 )adirecting group (DG) is typicallye mployed that, althoughu seful,m ight not be desired in the final product and, in many cases, is difficultf or follow-up syntheticm anipulation;3 )examples that use CÀHa ctivation in the construction of complex molecules are still relatively limited. [5] Herein, we report our realization of aM n/Ag based "catalyst relay" strategy [6] for the one-pot assembly of diversely functionalized indenoquinolines [7] bearing three consecutive stereogenic cen-ters and two quaternary carbons( Scheme 1a). The easily accessiblei mines erved as am ultifunctional directing group and 100 %a tom-economy was realized.…”

ZrCl4-Catalyzed Synthesis of Pyrimido[4,5-b]quinolin-2,4-(1H,3H)- diones and 11H-Indeno[1,2-b]quinolin-11-ones

“…环分子, 是多种生物碱的主要组成部分, 其 10-位含有 甲酯基的衍生物显示出良好的抗癌活性 [10] . 现有的这 类化合物的合成 [11] , 常需要多步反应才能实现, 尤其是 10-位含有甲酯基的 11H-茚并 [1,2-b]喹啉-11-酮衍生物 不易获得 [12] .…”

In–Vitro Anticancer and Antibacterial Activities of Brominated Indeno[1,2‐b]qinoline Amines Supported with Molecular Docking and MCDM**

“…The cytotoxicities of several of these tetracycles are comparable to or better than that of camptothecin. [22] Therefore, the indeno [1,2-b]quinolines are considered important pharmacophore scaffolds for the development of new therapeutic agents and DNA/BSA binding ligands. [23][24] The inhibition mechanism of DNA topoisomerase I and II by indeno [1,2-b]quinolines has not been fully elucidated.…”