Synthesis and drug release profile of a dual-responsive poly(ethylene glycol) hydrogel nanocomposite

Tenório‐Neto, Ernandes T.; Lima, Diego de Souza; Guilherme, Marcos R.; Lima-Tenório, Michele K.; Scariot, Débora B.; Nakamura, Celso Vataru; Kunita, Marcos H.; Rubira, Adley F.

doi:10.1039/c7ra02846f

Cited by 16 publications

(6 citation statements)

References 29 publications

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“…The constructing materials of the hydrogel were PEG hydrogel and the agar. PEG hydrogel was used extensively in scaffolds for engineering applications like articular cartilage, neural tissue, and bladder tissue regeneration [ [28] , [29] , [30] , [31] ]. Agar has already been adopted as the matrix for cell culture [ 32 , 33 ].…”

Section: Resultsmentioning

confidence: 99%

Synergistic therapy of magnetism-responsive hydrogel for soft tissue injuries

Zhang

Zuo

et al. 2019

Bioactive Materials

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Soft tissue injury is very common and associated with pain, tissue swelling and even malformation if not treated on time. Treating methods include cryotherapy, electrical therapy, ultrasound therapy and anti-inflammatory drug, but none of them is completely satisfying. In this work, for a better therapeutic effect, drug therapy and pulsed electromagnetic field (PEMF) therapy were combined. We constructed a drug delivery system using the tetra-PEG/agar hydrogel (PA). By incorporating Fe 3 O 4 NPs into the hydrogel network, a magnetism-responsive property was achieved in the system. The cytotoxicity and in vivo study showed a good biocompatibility of the PA/Fe 3 O 4 hydrogel. A magnetism-controlled release was attained by the incorporation of Fe 3 O 4 . Finally, in vivo study showed a better performance of the DS-loaded PA/Fe 3 O 4 compared with the commercially available DS ointment regarding the recovery of the injured soft tissue. Therefore, this magnetism-responsive hydrogel may represent a promising alternative to treat soft tissue injury.

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Section: Resultsmentioning

confidence: 99%

Synergistic therapy of magnetism-responsive hydrogel for soft tissue injuries

Zhang

Zuo

et al. 2019

Bioactive Materials

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“…Gelatin has many functional groups in its structure, so it can easily react with epichlorohydrin . Epichlorohydrin has been widely used in the preparation of different hydrogels for drug delivery purposes . Epichlorohydrin is toxic for prolonged high‐level oral consumption .…”

Section: Resultsmentioning

confidence: 99%

“…By definition, hydrogels are a kind of cross‐linked hydrophilic polymers which are able to absorb, swell, and retain a large quantity of water, saline, and other physiological solutions in their three‐dimensional structures, without being dissolved . Hydrogels are made up of water‐soluble polymers that are cross‐linked via chemical or physical bonds .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of gelatin‐based biodegradable hydrogel nanocomposite and their application as drug delivery agent

et al. 2018

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In this work, gelatin was chemically cross‐linked using epichlorohydrin. Then, a series of gelatin‐based hydrogel nanocomposites containing CuO nanoparticles were prepared by immersion of gelatin hydrogel in CuCl2 solution with different concentrations. Gelatin was chosen, due to its cheapness, nontoxicity, and biocompatibility. The structure and morphology of hydrogel nanocomposites were characterized by a number of techniques such as FT‐IR, XRD, energy dispersive X‐ray spectroscopy, and scanning electron microscopy. Then, swelling behavior of synthesized hydrogel nanocomposites in distilled water and different saline solutions was investigated. Their sensitivity to pH, biodegradability, and gel content was determined. Moreover, the water uptake and shrinking kinetics of hydrogel nanocomposites were evaluated. Finally, they were used as drug delivery agent, and the different concentrations effect of CuO nanoparticles present within the hydrogel nanocomposites compared with neat hydrogel on mentioned tests was studied.

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“…Recently, Ma et al combined two-photon AIE bioimaging and ROS-responsive drug delivery for the diagnosis and therapy of inflammation [ 118 ]. Prednisolone, a widely used anti-inflammatory glucocorticoid [ 119 ], was linked to the TP using an ROS-responsive bond to form a diagnosis therapy compound TPP, which was then encapsulated into the amphipathic polymeric PMPC–PMEMA micelles to obtain TPP@PMM. Once TPP@PMM was accumulated at inflammatory tissues, the aggregated micelles exhibited significant two-photon fluorescence emission and subsequently triggered micelle disintegration for precise drug delivery under the concentrated ROS stimulus [ 118 ].…”

Section: Ros-sensitive Nano-formulations For Atherosclerosis Applicationsmentioning

confidence: 99%

Recent Advances in ROS-Sensitive Nano-Formulations for Atherosclerosis Applications

Peng

Jin

et al. 2021

Pharmaceutics

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Over the past decade, ROS-sensitive formulations have been widely used in atherosclerosis applications such as ROS scavenging, drug delivery, gene delivery, and imaging. The intensified interest in ROS-sensitive formulations is attributed to their unique self-adaptive properties, involving the main molecular mechanisms of solubility switch and degradation under the pathological ROS differences in atherosclerosis. This review outlines the advances in the use of ROS-sensitive formulations in atherosclerosis applications during the past decade, especially highlighting the general design requirements in relation to biomedical functional performance.

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Synthesis and drug release profile of a dual-responsive poly(ethylene glycol) hydrogel nanocomposite

Abstract: This work describes the synthesis, characterization and application of a pH- and magnetic-responsive PEG hydrogel (HG) nanocomposite as a platform for drug delivery.

Cited by 16 publications

References 29 publications

Synergistic therapy of magnetism-responsive hydrogel for soft tissue injuries

Synergistic therapy of magnetism-responsive hydrogel for soft tissue injuries

Synthesis of gelatin‐based biodegradable hydrogel nanocomposite and their application as drug delivery agent

Recent Advances in ROS-Sensitive Nano-Formulations for Atherosclerosis Applications

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