Synthesis and DNA Topoisomerase‐II Inhibitory Activity of Unnatural Nucleosides.

Mishra, Rupesh K.; Dwivedi, Namrata; Tripathi, Rama Pati; Bansal, Iti; Saxena, Jitendra Kumar

doi:10.1002/chin.200712214

Cited by 5 publications

(5 citation statements)

References 2 publications

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“…The results of the enzyme inhibitory activity showed that only one of the compounds was active against the DNA-topo-II. Some of the unnatural nucleosides were found to cause degradation or cleavage of DNA in treated cells which indicated that they were acting as antineoplastic agents [101].…”

Section: Carbohydrate Derivatives As Antiparasitic Agentsmentioning

confidence: 99%

Spirocyclic Nucleosides in Medicinal Chemistry: An Overview

Soengas

Silva²

2012

MRMC

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Section: Carbohydrate Derivatives As Antiparasitic Agentsmentioning

confidence: 99%

Spirocyclic Nucleosides in Medicinal Chemistry: An Overview

Soengas

Silva²

2012

MRMC

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“…Growing this plant will certainly have the positive impacts on the environment, nutrition, and health. Consumption of it protects against diarrhoea, heart disease, eye disease, and a number of other illnesses [4]. Moringa leaves also possess the positive effect against inflammation, spasm, hypertension, tumour, ulcer, epilepsy, diabetes and hepato-proliferation.…”

Section: Introductionmentioning

confidence: 99%

Physico-chemical, optical, and functional characterization of the developed phytochemical rich water dispersible tablets from moringa leaf and wheat grass powder

Suraksha,

Jindal,

Prasad

2023

J. Phys.: Conf. Ser.

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Moringa oleifera is a well-recognized wonder plant with vigorous growth, great nutritional potential, and full of phytochemicals to add therapeutic and medicinal effects. Wheat grass also has proven health benefits like moringa. Moringa leaves and wheat grass were dehydrated in a cabinet drier and powdered. These powders were analysed for physicochemical, optical, nutritional, functional, rheological, structural, and phytochemical characteristics. The developed powders were rich in protein, phenolic content, and antioxidant potential to be used for prophylactic purposes. Antioxidant value was observed as 88.86±0.15, and 38.08±0.32 mg/g and the total phenolic content as 149.30±2.26 and 126.06±0.47 mg GAE/100g for the moringa leaf and wheatgrass powder, respectively. During storage at room temperature for three months the antioxidant potential was reduced to almost 10-15%. The rapid loss of vital phytochemicals happens due to the process of oxidation, as powders were having higher exposed surface area to volume. Wet granulation method was applied for tablet formation from moringa leaf and/or wheatgrass powder. The tablets were tested for weight variations, hardness, disintegration, sedimentation characteristics, wetting volume, wetting time, and functional characteristics. Insignificant change in the antioxidant activity and TPC were observed on converting the powders into tablets. The detailed phytochemicals as present in the developed tablets may find role in prophylactic and therapeutic applications.

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“…Numerous molecular targets are known for filarial parasites and few of them have been utilized as potent chemotherapeutic target (Mishra et al, 2005;Muller et al, 1988;Nagarajan et al, 1988;Singh et al, 2007;Singh et al, 2008). DNA topoisomerases are involved in managing the topological problems associated with DNA replication, transcription, recombination and chromatin remodeling by introducing temporary single or double stranded breaks in the DNA.…”

Section: Introductionmentioning

confidence: 99%