Synthesis and DNA interaction of ethylenediamine platinum(II) complexes linked to DNA intercalants

Duskova, Katerina; Sierra, Sara; Fernández, M. J.; Gude, Lourdes; Lorente, Antonio

doi:10.1016/j.bmc.2012.09.055

Cited by 22 publications

(6 citation statements)

References 39 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DNA binding with metallointercalators results in a covalent interaction, which causes disentanglement of the double helix to facilitate π -stacking interactions between the ring cloud of the base pairs and the intercalating planar aromatic systems. Although research into this subject dates back to the pioneering work of Lippard and co-workers in the late 1970s, many platinum complexes with pyridines [20], bipyridines [67], terpyridines [68], phenanthrolines [67,69,70], naphthalene [71], anthraquinones [72], and their derivatives continue to be synthesized and tested to assess their possible anticancer activity, effectiveness in DNA binding, DNA cleavage, and telomerase inhibition activity.…”

Section: Pt(ii) Complexes With Dna-intercalating Moleculesmentioning

confidence: 99%

Noble metals in medicine: Latest advances

Medici

Peana

Nurchi

et al. 2015

Coordination Chemistry Reviews

642

345

View full text Add to dashboard Cite

Section: Pt(ii) Complexes With Dna-intercalating Moleculesmentioning

confidence: 99%

Noble metals in medicine: Latest advances

Medici

Peana

Nurchi

et al. 2015

Coordination Chemistry Reviews

642

345

View full text Add to dashboard Cite

“…167 The tether often resides in the minor groove during these interactions. 156,168,169 Modulation of the I L s and types of tethers used can also lead to enhanced selectivity toward DNA sequences. 156,168,169 Modulation of the I L s and types of tethers used can also lead to enhanced selectivity toward DNA sequences.…”

Section: Bisintercalationmentioning

confidence: 99%

“…166 DNA binding affinities of most transition-metal based bisintercalators are higher than their mononuclear counterparts due to increased charge and aromatic surface area; this affinity can often lead to higher cytotoxicity. 156,168,169 Modulation of the I L s and types of tethers used can also lead to enhanced selectivity toward DNA sequences. 170,171 Bisintercalating platinum complexes are usually mononuclear with two tethers leading to I L s or multinuclear with an I L at each end (Fig.…”

Section: Mononuclear Complexesmentioning

confidence: 99%

Metal complex interactions with DNA

2015

View full text Add to dashboard Cite

Increasing numbers of DNA structures are being revealed using biophysical, spectroscopic and genomic methods. The diversity of transition metal complexes is also growing, as the unique contributions that transition metals bring to the overall structure of metal complexes depend on the various coordination numbers, geometries, physiologically relevant redox potentials, as well as kinetic and thermodynamic characteristics. The vast range of ligands that can be utilised must also be considered. Given this diversity, a variety of biological interactions is not unexpected. Specifically, interactions with negatively-charged DNA can arise due to covalent/coordinate or subtle non-coordinate interactions such as electrostatic attraction, groove binding and intercalation as well as combinations of all of these modes. The potential of metal complexes as therapeutic agents is but one aspect of their utility. Complexes, both new and old, are currently being utilised in conjunction with spectroscopic and biological techniques to probe the interactions of DNA and its many structural forms. Here we present a review of metal complex-DNA interactions in which several binding modes and DNA structural forms are explored.

show abstract

“…5 On the basis of the structural equivalence (for d 8 systems the squareplanar geometry is preferred) and thermodynamic variance of platinumĲII) complexes, there is much interest in the study of platinumĲII) complexes as potential anticancer drugs, especially with 5-quinoline based 1,3,5-tri-substituted pyrazole based ligands. [6][7][8][9][10] Quinolines are heterocyclic aromatic organic compounds containing nitrogen atoms. Quinoline derivative compounds are generally used as "parental" compounds to synthesize molecules with medical benefits, mainly with anti-microbial and anti-malarial activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biological application of 5-quinoline 1,3,5-trisubstituted pyrazole based platinum(ii) complexes

et al. 2018

View full text Add to dashboard Cite

Square planar mononuclear platinum(ii) complexes were synthesized in the presence of neutral bidentate heterocyclic (5-quinoline 1,3,5-tri-substituted pyrazole scaffold) ligands and KPtCl salt. The synthesized compounds were characterized by micro-elemental analysis, FT-IR, UV-vis, H NMR,C NMR, TGA, mass spectrometry and molar conductivity. Their biological activities were investigated by brine shrimp lethality bioassay, antimicrobial study against five different pathogens, cellular level cytotoxicity against cells, and anti-proliferation assay. The binding constant, , values of the complexes were determined by DNA interaction studies. The gel electrophoresis assay was carried out to examine the effect of the complexes on the DNA nuclease of pUC19 plasmid DNA. The docking energies of the ligands ( ) and complexes () were observed in the range of -265.14 to -284.33 kJ mol. The synthesized Pt(ii) complexes () were screened against the MCF-7 (human breast adenocarcinoma) and HCT-116 (human colon carcinoma) cancer cell lines.

show abstract

Synthesis and DNA interaction of ethylenediamine platinum(II) complexes linked to DNA intercalants

Cited by 22 publications

References 39 publications

Noble metals in medicine: Latest advances

Noble metals in medicine: Latest advances

Metal complex interactions with DNA

Synthesis, characterization and biological application of 5-quinoline 1,3,5-trisubstituted pyrazole based platinum(ii) complexes

Contact Info

Product

Resources

About