Synthesis and DNA cleavage studies of novel quinoline oxime esters

O-Benzoyl pyridine aldoxime and amidoxime derivatives: novel efficient DNA photo-cleavage agents

“…Thus, amidoximes are bi-functional molecules which exhibit a rich chemistry, providing among others one of the shortest ways to reach various heterocycles. 36 Compounds containing N-O bonds (aldoximes and ketoximes included) have been found to be efficient metal-free artificial DNA photo-cleavers 16,17,19,[37][38][39] due to the homolysis of the weak N-O bonds. Furthermore, their ability to complex with metals allows them to act as radiopharmaceuticals and antipollutants.…”

“…Furthermore, their ability to complex with metals allows them to act as radiopharmaceuticals and antipollutants. The fact that the number of aldoximes acting as efficient photo-cleavers is limited 19 prompted us to study novel scaffolds and provide a structure-activity relationship based on electronic phenomena on the ester conjugates (electron donor or acceptor) as well as steric factors and hydrogen bonding capacities (H vs. NH 2 ). 24c Additionally, charged 31,32 as well as uncharged derivatives 33-35 are efficient reactivators of nerve agent inhibited acetylcholinesterases aiming treatment for organophosphorous compound poisoning.…”

Anti-proliferative and ADMET screening of novel 3-(1H-indol-3-yl)-1, 3-diphenylpropan-1-one derivatives

“…Indolyl chalcones were found to be promising candidates for in vitro antitumor activity (Magdy & Atef, 2009;Magdy, Hanan, Yasmin, & Gamal-Eldeen Amira, 2010), as they were previously reported to possess anticancer Bindu, Mahadevan, Satyanarayan, & Ravikumar Naik, 2012), immunosuppressant and therapeutic activities for autoimmune diseases (Shum-ichi et al, 1999).…”

Synthesis, crystal structure, ABTS radical-scavenging activity, antimicrobial and docking studies of some novel quinoline derivatives

“…The literature survey revealed that, the synthetic quinoline and substituted quinoline derivatives are associated with a wide range of biological properties in curing a lot of diseases. Amongst them, quinoline esters are one of the most important derivatives, however only few methods have been reported in the literature [22][23][24][25][26][27][28][29][30][31][32] for their synthesis. Recently, quinoline-4-methyl esters are found to serve as human non pancreatic secretory phospholipase A2 inhibitors [33] and quinoline dicarboxylic esters are used as biocompatible fluorescent tags [34].…”