Synthesis and DNA cleavage activity of triazacrown-anthraquinone conjugates

Synthesis and the characterization of Schiff-base copper complexes: Reactivity with DNA, 4-NPP and BNPP

“…Structurally, complex 2 contains more planar polycyclic rings than complex 1. Complexes with planar polycyclic rings as part of the ligand moiety have been found to be good DNA intercalators [54][55][56][57][58]60].…”

“…Varying the ligands could tune the reactivity of the complex towards DNA. Planar ligands with pi systems have been noted to be good intercalators [54][55][56][57][58]. The planarity of such ligands contributes to the intercalating mode of binding of the complex to DNA.…”

Comparison of catalytic activities of new La (III) and Ce (III) complexes with different diaza-crown ether ligands for DNA hydrolytic cleavage

“…To gain insight into the probable mechanism of plasmid DNA cleavage (via an oxidative or hydrolytic pathway) by the LaL and CeL complexes, the typical scavengers for reactive oxygen species (ROS) [7,25,26], including NaN 3 (10 mmol L −1 ) as a singlet ( 1 O 2 ) scavenger, KI (10 mmol L −1 ) as a peroxide (O 2 2− ) scavenger, and t-BuOH and DMSO (1 mmol L −1 ) as hydroxyl radical (OH • ) scavengers, were also introduced, respectively, to the DNA cleavage assays ( Figure 5), as in our previous reports [14,17]. Figure 5 shows that none of these typical radical scavengers display any evident inhibition effect on the DNA cleavage efficiency, which suggests that ROS are not involved in the cleavage process, at least in a free and diffusible form www.prkm.co.uk [25,27,28].…”

Zinc, copper and nickel derivatives of 2-[2-bromoethyliminomethyl]phenol as topoisomerase inhibitors exhibiting anti-proliferative and anti-metastatic properties

“…Densitometric quanti-cation of supercoiled DNA and cleavage products aer electrophoresis was estimated using TotalLab Quant soware. 34,67 Supercoiled plasmid DNA values were corrected by a factor of 1.3 due to the lowered binding of ethidium to this structure. [68][69][70] To study the DNA cleavage mechanism, several radical scavengers (Tiron, thiourea, DMSO, and sodium azide) and a specic Cu(I) chelator (neocuprione) were used.…”