Synthesis and dissolved hyperpolarized xenon NMR studies of sucrose octaoleate-F104

19F magnetic resonance imaging using vesicles of sucrose octaoleate-F104

“…The success of hyperpolarized xenon imaging will depend ultimately on the rate of the xenon depolarization, hence long 129 Xe spin lattice relaxation times (T 1 ) are of critical importance. The observed T 1 value in above-mentioned EYP emulsion was 15 s [3], which would appear to present a substantial impediment for the eventual use of such a method for MRI applications.…”

“…Recently [3], we have synthesized sucrose octaoleate-F 104 and used it in an emulsion containing egg yolk phospholipid (EYP) to encapsulate hyperpolarized xenon gas. In this work, we explored the possible use of this system in vitro as part of an eventual biocompatible in vivo delivery systems for hyperpolarized xenon in functional 129 Xe MRI [4,5].…”

Synthesis of highly fluorinated fatty acid esters of glycerol:glycerol tripalmitate-F39

“…Current initiatives in this laboratory have been directed towards the synthesis of highly fluorinated fatty acids [1,2] and their polyesters with sucrose [3] which are of potential application in the preparation of novel biocompatible delivery systems for dissolved hyperpolarized xenon to be used in functional 129 Xe magnetic resonance imaging (MRI) [4]. The highly fluorinated sucrose polyesters have been chosen for study since it is known [5] that the human lipase enzyme cannot metabolize sucrose polyesters in which more than five of the eight OH groups have been esterified with long chain fatty acids and hence these materials pass unmetabolized through the human gastrointestinal tract.…”

“…Accordingly the application of such compounds as part of a biocompatible 129 Xe carrier for functional imaging of Crohn's disease and other gastrointestinal disorders can be envisaged. Our recent work [3] on sucrose octaoleate-F 104 demonstrated that this material, when present in an aqueous emulsion with egg yolk phospholipid, is an efficient carrier of dissolved hyperpolarized 129 Xe gas.…”