Synthesis and Development of a Nonaflate Ester in the Large-Scale
Preparation of 3-Deoxymorphine
Antonio M. Ruda,
Jonathan D. Moseley
Abstract:A series of novel activated esters of morphine were synthesized as alternatives to the triflate
ester and submitted to hydrogenolysis conditions. Of these, only the novel nonaflate ester could
be transformed with full conversion into the useful intermediate, 3-deoxymorphine, which was isolated
in good yield and high purity without chromatography. This conversion proceeded significantly
faster than for the triflate ester and with synthesis of the intermediate nonaflate at much reduced cost,
an important factor … Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.