Synthesis and determination of the stereochemistry of 23,25-dihydroxy-24-oxovitamin D3, a major metabolite of 24(R),25-dihydroxyvitamin D3

Yamada, Sachiko; Yamamoto, Keiko; Ino, Eiichi; Sakaida, Kazumasa; Takayama, Hiroaki; Shinki, Toshimasa; Suda, Toshio; Iitaka, Yōichi; Itai, Akiko

doi:10.1021/bi00437a007

Search citation statements

Order By: Relevance

Paper Sections

Select...

Vitamins D Their Derivatives and Their Metabolites1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1991

2000

Publication Types

Select...

Article6

Relationship

Self Cite0

Independent6

Authors

Journals

Cited by 7 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The C-23 epimers of the major metabolite (384) of 24(R)hydroxycalciodiol have been synthesized and their configurations at C-23 have been determined by X-ray analysis. 176 The naturally occurring epimer of the 24-0x0 compound (384) is found to have the S configuration at C-23 by comparison of its spectral properties and HPLC behaviour with those of the synthetic isomers. The 22-hydroxy-and 22-methoxy-derivatives (385) and (386) of calcitriol are prepared from the 22-aldehyde (387).17' The 22(S)-epimers show much more potent biological activities.…”

Section: Vitamins D Their Derivatives and Their Metabolitesmentioning

confidence: 99%