Synthesis and determination of antimycobacterial activity of tryptanthrine, vasicine, vasicinone and derivatives thereof

Expeditious Approach to Indoloquinazolinones via Double Annulations of o-Aminoacetophenones and Isocyanates

“…Quinazolinone and indole are two important structural motifs which can be found in many natural products and synthetic pharmaceutical compounds, exhibiting a broad spectrum of biological activities. Indole-fused quinazolinones such as indoloquinazolinone derivatives are shown to possess a variety of promising biological activities, including antibacterial, anticancer, and antifungal activities . One typical example is tryptanthrin (6-oxo indolo­[1,2- b ]­quinazolinone), which has been found in many kinds of plants , and exhibits intriguing biological properties such as anticancer, antibacterial, antifungal antiprotozoal, antiparasitic, and antitubercular activities. , As such, the indole-fused quinazolinones have attracted considerable attention as a pharmacophore.…”