Synthesis and determination of absolute configuration of R-?-amino-benzylphenylphosphinic acid

Synthesis of α‐aminophosphinates by the hydrophosphinylation of imines

“…Belov et al [10] isolated a single enantiomer of ethyl α-benzylaminophenylphosphinic acid by repeated recrystallization from a diastereomeric mixture followed by resolution and determined the absolute configuration by X-ray crystallography. A short report was also published on the diastereoselectivity of the addition of ethyl phenyl-H-phosphinate on several imines prepared from isobutyraldehyde and different type of benzyl and α-substituted benzylamines [11].…”