Synthesis and degradation mechanism of renally excretable gold core–shell nanoparticles for combined photothermal and photodynamic therapy

Abstract

Photothermal therapy using Zein gold nanoshell as a potent therapeutic aproach in the treatment of tumors.

Influence of PEGylation on WS2 Nanosheets and Its Application in Photothermal Therapy

“…The in vitro photothermal evaluation of the material was evaluated on the MDAMB-231 breast cancer cell line. 36 The cells were seeded in a 96-well plate, which was replaced with the WS 2 material (corresponding to 25 ppm tungsten) dispersed in fresh media after the cells are allowed to attach for 24 h. A 808 nm wavelength laser was irradiated for 5 min at a power of 1 W cm −2 . The cells were incubated with the PEG:WS 2 nanosheets for 24 h, followed by washing with PBS.…”

Light‐Responsive Nanoassemblies: Advancing Biomedical Innovation

“…The next aspect of nanoassemblies biosafety focuses on their excretion pathway and time. [ 2b,204 ] Ideally, the administered nanoparticles will be preferentially excreted from the human body via the renal pathway. This restricts body exposure by minimizing cellular internalization during circulation.…”

“…It was however reported that the majority of nanoparticles administered are captured by the MPS of major organs potentially causing severe in vivo toxicity. [ 204 ] The core factors influencing the excretion pathway of nanoassemblies include their size and surface functionality. [ 2b ] Nanoassemblies with a size smaller than 6 nm are mostly excreted via the hepatic pathway (i.e., liver metabolism, bile excretion, and defecation).…”

Preclinical safety assessment of red emissive gold nanocluster conjugated crumpled MXene nanosheets: a dynamic duo for image-guided photothermal therapy

“…According to the findings of the ROS study, laser therapy can lead to the pro-duction of reactive oxygen species ( photodynamic therapy), which may contribute to the increased cancer cell mortality rate. 75…”