Synthesis and cytotoxicity of epoxide and pyrazole analogs of the combretastatins

Syntheses and Cytotoxic Properties of the Curcumin Analogs 2,6‐Bis(benzylidene)‐4‐phenylcyclohexanones

“…The cytotoxicity of curcumin analogs 1-9, 11-15 was assessed in B16 (murine melanoma) and L1210 (murine leukemia) cell lines using a 72 h continuous exposure MTT assay as previously described [14]. The concentration at which 50% cell growth was inhibited (IC 50 , μM) was determined for each compound in triplicate experiments.…”

“…L1210 and B16 cell lines were purchased from ATCC (Manassas, VA, USA) and were maintained as previously reported [14]. The microtubule disrupting effects were evaluated in A-10 cells by indirect immunofluorescent techniques as previously described [24].…”

“…Curcumin analogs 1-15 were subjected to a continuous exposure 72 h MTT assay as described previously [14]. L1210 and B16 cell lines were purchased from ATCC (Manassas, VA, USA) and were maintained as previously reported [14].…”

“…This is of particular interest to one of the author's laboratory, which has extensively studied the effects of combretasta-tin-A4 analogs, such as chalcones and diarylheterocycles, as mitotic inhibitors. Presumably, cytotoxicity is mediated, at least in part, by microtubule depolymerization and inhibition of tubulin polymerization [12][13][14][15][16][17].…”

Synthesis and Antimicrobial Activity of Pyrrolyl/Pyrazolyl Arylaminosulfonylmethyl 1,3,4-Oxadiazoles, 1,3,4-Thiadiazoles and 1,2,4-Triazoles

“…10,11) Further, 1,3,4-oxadiazoles are very good bioisosteres of amides and esters which can contribute substantially in increasing pharmacological activity by participating in hydrogen bonding interactions with the receptors. 12) Besides, it has been well documented that pyrazoles 13) and oxadiazoles 14,15) have cytotoxic activity. The therapeutic effects of compounds containing 1,3,4-thiadiazole rings have been studied for a number of pathological conditions including inflammation, 16,17) pain 18,19) and hypertension.…”