Synthesis and cytotoxicity against tumor cells of pincer N-heterocyclic ligands and their transition metal complexes

Abstract

The complexes: [CoL2](ClO4)2 (1), [FeL2](ClO4)2 (2), [NiL2](ClO4)2 (3) and [MnLCl2] (4), with L = diethyl-1,1′-(pyridine-2,6-diyl)bis(5-methyl-1H-pyrazole-3-carboxylate), were synthesized and fully characterized.

Novel family of bis-pyrazole coordination complexes as potent antibacterial and antifungal agents

“…The bond angles on the equatorial plane range between 85.54(8)-94.94 (9) . The pyrazolic nitrogen atoms at axial positions are located at a distance of 2.155(2) and 2.158(2) A, and form angles with the metal centre that fall in the range of 76.96(8)-99.80 (8) , respectively.…”

“…Additionally, the bond angles on the equatorial plane range between 87.35(8)-96.7 (1) . The pyrazolic nitrogen atoms at axial positions are located at a distance of 2.274(2) and 2.304(2) A and form angles with the metal centre that fall in the range of 73.87(7)-98.96 (8) , respectively. The local distortion parameter around the metal ion is S HS ¼ 73.42 .…”

“…More specically, pyrazole-based ligands have proven their efficiency for the construction of coordination complexes with useful applications in several elds not only in catalysis, 1 agricultural biotechnology, 2 corrosion inhibition, antimicrobial activity 3 and biology, 4 but also in pharmaceutical and medical research, 5 leading for instance to anti-inammatory 6,7 and anti-cancer agents. 8 According to recent literature reports, 9,10 the preparation of pyrazole based ligands with multiple coordination sites remains a challenging task. Such ve-membered heterocyclic ligands associated with hydrogen bonding as well as p-p interactions can lead to interesting features, such as exibility, ductility and chelation properties for the resulting coordination complexes.…”

“…More specifically, pyrazole-based ligands have proven their efficiency for the construction of coordination complexes with useful applications in several fields not only in catalysis, 1 agricultural biotechnology, 2 corrosion inhibition, antimicrobial activity 3 and biology, 4 but also in pharmaceutical and medical research, 5 leading for instance to anti-inflammatory 6,7 and anti-cancer agents. 8…”

Synthesis, characterization, biological potency, and molecular docking of Co2+, Ni2+ and Cu2+ complexes of a benzoyl isothiocyanate based ligand

“…Heterocycles are highly active parts of cancer medications, some of which are linked to metallic complexes. For instance, nitrogen-donor chelating ligands have been frequently exploited in the architectural design of metal complexes with biological purposes, comprising cytotoxic actions 1 – 3 . In this case, an array of 5-iodouracil complexes with Co 2+ and Cu 2+ ions were produced, some of which were potent against Sarcoma-180 and L929 cell tumors 4 .…”