Synthesis and cytotoxic activity of N-substituted thiosemicarbazones of 3-(3,4-methylenedioxy)phenylpropanal

Silva, Maria Joselice e; Alves, A. J.; Nascimento, Silène Carneiro do

doi:10.1016/s0014-827x(97)00022-0

Cited by 8 publications

(7 citation statements)

References 11 publications

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“…Como mencionado anteriormente, as tiossemicarbazonas pertencem a uma classe de substâncias bastante conhecidas por suas aplicações importantes na pesquisa de novos fármacos, em função de seu largo espectro de ação 78 . Alguns autores atribuem esta propriedade à alta afinidade que as tiossemicarbazonas apresentam pela enzima ribonucleotídeo redutase, responsável pelo passo crucial na síntese do DNA e, conseqüentemente, da divisão celular 1,2 .…”

Section: Considerações Biológicas De Tiossemicarbazonas E De Alguns Dunclassified

Tiossemicarbazonas: métodos de obtenção, aplicações sintéticas e importância biológica

Tenório¹,

Góes²,

Lima³

et al. 2005

Quím. Nova

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Section: Considerações Biológicas De Tiossemicarbazonas E De Alguns Dunclassified

Tiossemicarbazonas: métodos de obtenção, aplicações sintéticas e importância biológica

Tenório¹,

Góes²,

Lima³

et al. 2005

Quím. Nova

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“…Thiosemicarbazone derivatives have a wide range of pharmacological properties. For example, 3′,4′-(methylenedioxy)acetophenone thiosemicarbazone derivatives show cytotoxic activity against KB cells (Silva et al, 1998). As part of our study on the synthesis of thiosemicarbazone derivatives, we report herein the crystal structure of a new 3′,4′-(methylenedioxy)acetophenone thiosemicarbazone derivative.…”

Section: S1 Commentmentioning

confidence: 99%

1-(2H-1,3-Benzodioxol-5-yl)ethanone thiosemicarbazone

et al. 2013

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In the title compound, C10H11N3O2S, the 1,3-benzodioxole and hydrazinecarbothioamide fragments are nearly planar [(mean deviations from planarity for non-H atoms of 0.0325 (12) Å and 0.0707 (10) Å, respectively] and subtend a dihedral angle of 29.06 (5)°. In the crystal, molecules are linked by pairs of almost linear N—H⋯S hydrogen bonds, forming inversion dimers. These dimers are additionally connected by weaker and strongly bent N—H⋯S interactions into chains along [101]. There is one additional weak N—H⋯O contact which, if considered as an interaction, leads to the formation of a three-dimensional network.

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“…Metal complexes of the Schiff bases possess numerous applications including antibacterial, antifungal and other biological applications, as well as clinical, analytical and industrial in addition to their important roles in catalysis. Thiosemicarbazones and semicarbazones compound possessing varied significant biological activity have been reported, such as antifungal (Nath et al, 2000;Thanh et al, 2015;Reis et al, 2013), antibacterial (Kalaivani et al, 2012;Singh et al, 2014), antitumor (Tojal, 2012;Arora et al, 2014), anti-Inflammatory (Asif and Husain, 2013), antileukemia (Pahontu et al, 2015), cytotoxic (Silva et al, 1998), antioxidant (Singhal et al, 2011), anticonvulsant (Kumar and Raj, 2013), and anticancer (Naidu and Kinthada, 2012;Kulandaivelu et al, 2011), activities. Metal complexes of the Schiff bases possess numerous applications including antibacterial, antifungal, antiviral, anticancer and other biological applications, as well as clinical, analytical and industrial in addition to their important roles in catalysis.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and spectral, antibacterial, molecular studies of biologically active organosilicon(IV) complexes

Singh

Bhanuka

2017

Journal of the Association of Arab Universities for Basic and A

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A series of new organosilicon(IV) complexes have general formulae R 3 SiL and RSiLOEt with Schiff bases (R = Me and Ph). The Schiff bases (LH) have been derived from the condensation of (2-hydroxyphenyl)(pyrrolidin-1-yl)methanone with semicarbazide, thiosemicarbazide, and phenylthiosemicarbazide, respectively. The compounds have been characterized by the elemental analysis, molar conductance, and spectral (UV, IR, 1 H, 13 C, and 29 Si NMR) studies. These studies showed that the ligands coordinate with the silicon atom in a tridentate manner through phenolic oxygen, azomethine nitrogen and thiolic sulfur. Further applying experimental spectroscopic techniques, theoretical data calculated using density functional theory by B3LYP/6.31+g(d,p) has also been used for structural determination. The resulting complexes have been proposed to have trigonal bipyramidal and distorted octahedral geometries. Few representative Schiff base and their silicon complexes have been screened for their in vitro antibacterial activity against Gram-positive and Gram-negative bacteria. The minimum inhibitory concentration (MIC) of selected compounds was determined. The screening results show that organosilicon(IV) complexes have better antibacterial activity than the free ligands.

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Synthesis and cytotoxic activity of N-substituted thiosemicarbazones of 3-(3,4-methylenedioxy)phenylpropanal

Cited by 8 publications

References 11 publications

Tiossemicarbazonas: métodos de obtenção, aplicações sintéticas e importância biológica

Tiossemicarbazonas: métodos de obtenção, aplicações sintéticas e importância biológica

1-(2H-1,3-Benzodioxol-5-yl)ethanone thiosemicarbazone

Synthesis and spectral, antibacterial, molecular studies of biologically active organosilicon(IV) complexes

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