Synthesis, and Cytotoxic Activity of Nind-Alkoxy Derivatives of Antibiotic Arcyriarubin and Dechloro-rebeccamycin Aglycon.

Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids

“…In addition to the synthesis of the natural indolocarbazole alkaloids described above, a large variety of synthetic indolocarbazoles has been reported in order to develop potential candidates for the treatment of cancer and other diseases. ,,,− A quite interesting approach was developed by Meggers and co-workers, who prepared a range of carbazole–metal complexes that are inspired by staurosporine ( 30.3 ) and analogues. − …”

Simple indole alkaloids and those with a nonrearranged monoterpenoid unit

“…The first enantioselective total synthesis of (ϩ)-austamide (180) and its naturally occurring relatives (ϩ)-deoxyisoaustamide (181), and (ϩ)-hydratoaustamide (182b) have been achieved starting from -tryptophan methyl ester (183) (Scheme 30). 102 The key step of the synthesis is a new one step palladiummediated conversion of an N-prenylated tryptophan derivative (184) to the dihydroindoloazocine tricycle (185). Fmoc cleavage of 185, followed by heating of the resulting amino ester, produced the diketopiperazine (186a), which was then converted into (ϩ)-180 through (ϩ)-hydratoaustamide (182b) in three steps.…”

Chemoselective and Enantioselective Oxidation of Indoles Employing Aspartyl Peptide Catalysts

“…Reactivity may be diverted from the desired formation of 3 to the observation of N -hydroxy-indoles ( 6 ) and indole-ring hydroxylation. 9 Thus, complications are often encountered with a variety of metal-catalyzed, dioxirane- or oxaziridine-mediated approaches.…”