1991
DOI: 10.1016/0223-5234(91)90153-e
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Synthesis and cytotoxic activity of 5-(1-hydroxy-2-haloethyl)-, 5-oxiranyl- and (E)-5-(2-iodovinyl)-2,4-dichloro (or dimethoxy) pyrimidines

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Cited by 3 publications
(6 citation statements)
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“…In earlier studies, 16 we observed that in addition to 5-alkyl side chains, 5-alkylalkynyl (5-decynyl and 5-dodecynyl) moieties at the C-5 position of the specific N-1 substituted pyrimidines also contribute to significant antimycobacterial activities. Therefore, to further establish the structural requirements at the 5-position of pyrimidines for antimycobacterial activity, we explored various 5-alkyl (or aryl)alkynyl pyrimidines (17)(18)(19)(20)(21)(22)(23)(24)(25)(26). Within these, 5-alkylalkynyl substituted pyrimidines (17-22, Table 1) were found to be inactive as antimycobacterial agents despite their varying chain lengths at the C-5 position.…”
Section: Resultsmentioning
confidence: 99%
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“…In earlier studies, 16 we observed that in addition to 5-alkyl side chains, 5-alkylalkynyl (5-decynyl and 5-dodecynyl) moieties at the C-5 position of the specific N-1 substituted pyrimidines also contribute to significant antimycobacterial activities. Therefore, to further establish the structural requirements at the 5-position of pyrimidines for antimycobacterial activity, we explored various 5-alkyl (or aryl)alkynyl pyrimidines (17)(18)(19)(20)(21)(22)(23)(24)(25)(26). Within these, 5-alkylalkynyl substituted pyrimidines (17-22, Table 1) were found to be inactive as antimycobacterial agents despite their varying chain lengths at the C-5 position.…”
Section: Resultsmentioning
confidence: 99%
“…Synthesis of 5-alkyl uracils (9-16) (Scheme 1) was carried out using reported procedures described by us earlier. 18 5-Alkynyl pyrimidines (17-22, 24, 25) were prepared by the Pdcatalyzed coupling reaction of 5-iodoracil (5) with appropriate alkylacetylenes, arylacetylenes, and para substituted arylacetylenes to yield the target 5-alkynyl pyrimidines 17-22, 24, 25 as described in Scheme 2. The 5-(2-phenylethynyl)-uracil (23) was synthesized using a previously reported method.…”
Section: Chemistrymentioning
confidence: 99%
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