Synthesis and cytotoxic activities of organometallic Ru(II) diamine complexes

Kavukcu, Serdar Batıkan; Şahın, Onur; Vatansever, Hafize Seda; Kurt, Feyzan Özdal; Korkmaz, Mehmet; Kendirci, Remziye; Pelit, Levent; Türkmen, Hayati

doi:10.1016/j.bioorg.2020.103793

Cited by 11 publications

(10 citation statements)

References 45 publications

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“…In our previous studies, we investigated the cytotoxic activities of RAED‐type monometallic and bimetallic ruthenium(II) arene complexes in various cancerous and healthy cell lines 22 . Our studies encouraged us to study the biological activities of new RAED‐type complexes.…”

Section: Resultsmentioning

confidence: 99%

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Ruthenium compounds: Are they the next‐era anticancer agents?

Kavukcu,

Özverel,

Kıyak

et al. 2024

Applied Organom Chemis

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This study focuses on the cytotoxic activity of ruthenium(II) complexes, denoted as Ru1–8, which exhibit coordination with nitrogen (amine and amide), oxygen, and sulfur donor atoms, coupled with aryl and aliphatic wingtips. Specifically, the complexes were evaluated for their impact on the MCF‐7 breast cancer cell line. A systematic exploration of various parameters, including solubility, donor atom type, metal number, carbon chain length, aromatic ring presence, and molecular weight, was conducted to discern their influence on cytotoxic activity. The investigation involved assessing the cell viability across five concentrations (100, 50, 25, 10, and 5 μM) for five distinct monometallic and three bimetallic ruthenium complexes. Notably, Ru3, characterized by an extended carbon chain length (dodecyl) and favorable oil solubility facilitating cellular membrane penetration, demonstrated particularly promising results with the IC50 value of 1.03 μM. This research underscores the critical role of ligand design in shaping the cytotoxic potential of ruthenium(II) complexes and emphasizes the suitability of the Ru(II) p‐cymene complexes, as demonstrated by their robust activity against breast cancer in this specific investigation.

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Section: Resultsmentioning

confidence: 99%

“…healthy cell lines. 22 Our studies encouraged us to study the biological activities of new RAED-type complexes. In this context, we prepared a series of monometallic and bimetallic complexes containing different aromatic and aliphatic groups.…”

Section: Chemistrymentioning

confidence: 92%

Ruthenium compounds: Are they the next‐era anticancer agents?

Kavukcu,

Özverel,

Kıyak

et al. 2024

Applied Organom Chemis

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“…12). The ability to decrease the (η/η 0 ) 1/3 of DNA varies in the order is: IV > VI > I > V > II > L 4 > L 6 > II > L 2 > L 1 > L > L 5 , which parallels the DNA binding a nity. The increase in viscosity, observed in the presence of complex (I-VI) is small compared to the classical DNA intercalator EB [24].…”

Section: Viscosity Measurementmentioning

confidence: 94%

“…Metal plays an important role in the function of enzymes and proteins. For enhancing the biological activities, researchers are focussing on metal compounds [1][2][3][4][5], and the metal carbonyls are important for pharmaceutical and diagnosis. Metal carbonyls are coordination complexes of transition metals having carbon monoxide as a ligand.…”

Section: Introductionmentioning

confidence: 99%

“…IR Spectra (KBr, 4000-400 cm − 1 ): 3259 v(-NH)stret., 3005 v(-CH)stret. alkane, 2843 v(= CH)stret., 2334 v(-C-N)stret., 1516, 1485 v(C = N), 1215 v(C = C)stret., 999 v(para substitution), 590, 630 v(C-Cl).4.4 General method for synthesis of -N,N donor complexes (I-VI)Ethanolic solution of the precursor of [Re(CO)5 Cl] (0.220 g, 0.8 mmol) was re uxed for 10 minutes. Then a solution of ligand (L 1 -L 6 ) (0.300 g, 0.6 mmol in 10mL ethanol), was added and the reaction was stirred yielding a brownish red solution.…”

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Biomolecular Interaction, Antibacterial and Anticancer Activities of Organometallic Re(I) Complexes with 5-(2-butyl-5-chloro-1H-imidazol-4-yl)-1,3-diaryl-4,5-dihydro-1H-pyrazole

Varma

Pandya

Vaidya

et al. 2021

Preprint

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Organometallic rhenium(I) complexes (I-VI) using substituted 5-(2-butyl-5-chloro-1H-imidazol-4-yl)-1,3-diaryl-4,5-dihydro-1H-pyrazole have been synthesized and characterised by spectroscopic method. For evaluation of HOMO-LUMO energy gap, estimation of bond angle, bond length data and Mulliken charge analysis DFT studies were performed. The complexes (I-VI) can be generated by bis-heterocyclic ligand followed by metal chelation. The interactions between synthesised compounds and double stranded DNA (HS DNA) was carried out by viscosity measurements, absorption titration, and gel electrophoresis gives information about modes of binding and the nucleolytic efficiency of compounds. Groove binding was suggested as the most possible mode and the DNA-binding (Kb) constants of the complexes were calculated. Electronic spectra and conductivity measurement confirm the different transition, and non-electrolytic nature of the metal complexes. Thermodynamic parameter ΔG0 value ranging from -7227.0 to -9463.0 J/moleoK. According to the thermodynamic parameter, the main binding force could be judged. In vivo and In vitro cytotoxicity against the eukaryotic and prokaryotic cells gives toxic nature of the synthesised compounds. An antimicrobial study was carried out by estimating MIC (Minimum Inhibitory Concentration) against two Gram-positive and three Gram-negative bacteria. All compounds found effective against S. cerevisiae which is confirmed by enhancing ROS production and DNA damage show by gel electrophoresis as compared to untreated yeast cell culture and DMSO.

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