Synthesis and crystal structures of Schiff base zinc(III) complexes with antibacterial activity

Zhang, J.; Pan, Fanda; Cheng, Huilin; Du, Wei

doi:10.1134/s1070328410070067

Cited by 13 publications

(4 citation statements)

References 13 publications

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“…Compounds containing azomethine group (RC=N-) were named Schiff base after Hugo Schiff 1 and are usually formed by the condensation of a primary amine with an active carbonyl compound. Schiff base metal complexes with Schiff base ligands have been prepared and presented in numerous reports ranging from the purely synthetic [2][3][4][5][6][7][8] to modern physicochemically such as catalytic application 9 , optical material 10 , dyes, luminophores 11 and polymer with conductance properties 12 to biochemically relevant studies of these complexes in the points of view such as biologically active substances, antitumor 13 , antivirial 14 and antifungal 15 . Because of these applications, synthesis of new Schiff bases and their metal complexes are still the aim of many recent investigations.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral and Thermal Behavior of Some New Four Coordinated Complexes

Montazerozohori

Khani

Joohari

et al. 2011

Journal of Chemistry

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A new symmetric bidentate Schiff baseN, N′bis(4-fluorobenzal-dehydene)-1,2-diaminoethane(L) and its complexes with general formula MLX2(M= Zn(II), Cd(II) and Hg(II) and X=chloride, bromide, iodide, thiocyanate and azide) have been prepared. The ligand and complexes have been established by microanalysis, electronic, FT-IR,1H and13C NMR spectra, and by molar conductivity measurements. All compounds are non-electrolytes in chloroform or DMSO-d6. The thermal behavior of the complexes shows weight loss by decomposition of the anions and ligand segments in the subsequent steps. Some activation thermodynamic parameters such as E*, ∆H*, ∆S* and ∆G* were calculated from thermal analysis.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral and Thermal Behavior of Some New Four Coordinated Complexes

Montazerozohori

Khani

Joohari

et al. 2011

Journal of Chemistry

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“…HSA is the most prevalent protein in the blood that functions as a transporter for a number of chemicals. [33][34][35][36] Therefore, it is crucial to evaluate the ability of the target molecule to bind with DNA and HSA before evaluating its anticancer properties.…”

Section: Introductionmentioning

confidence: 99%

DNA/HSA binding and anticancer properties of pendant acetate bearing mono-nuclear Ni(ii) and bridging acetate bearing di-nuclear Cu(ii) Schiff base complexes: an experimental and molecular docking study

Ari,

Das,

Brandao

et al. 2023

New J. Chem.

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Section: Introductionmentioning

confidence: 99%

“…Human serum albumin (HSA), most plentiful circulating protein in human blood plasma, can effectively act as a drug delivery vehicle to transport the drug molecule to the target place, [35] and the drug molecule will get less scope to expose itself to the normal cell, leading to the decreases of side effect. [36,37] So to design an effective metal based anticancer agent, it is an urgent need to investigate the interaction potentiality of it with DNA and HSA. To address all these points in the present work, herein, two Schiff base Cu(II) complexes (1, 2) and Ni(II) complex (3) have been synthesized by employing the Schiff base ligand HL based on salicylaldehyde and pyridine platform.…”

Section: Introductionmentioning

confidence: 99%

Development of DNA intercalative, HSA binder pyridine‐based novel Schiff base Cu(II), Ni(II) complexes with effective anticancer property: A combined experimental and theoretical approach

Satapathi¹,

Das²,

Rajak

et al. 2021

Applied Organom Chemis

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The two novel Cu(II) complexes [Cu(L)(CH 3 COO)] and [Cu(L)(N 3 )] (1, 2) and one Ni(II) complex [Ni(L)(N) 3 ] (3) have been developed by using the ligand HL, obtained by the condensation of 2 amino methyl pyridine and 5-bromo salicylaldehyde. All the three complexes are spectroscopically characterized along with molar conductance measurement. With the help of EPR, density functional theory (DFT) studies, the occupants of distorted square planer geometry with azide (2 and 3), acetate (1) as a secondary anionic residue, and the presence of +2 oxidation state on metal center of the complexes have been documented. After structural determination, all the complexes have been exposed to inspect their DNA and human serum albumin (HSA) binding efficacy. Initially, the higher binding constants, obtained from electronic titration among complexes and DNA, the impressive reduction of fluorescence intensities of the HSA and Ethidium Bromide (EtBr)-DNA adduct, after incremental addition of complexes separately, assure the high binding ability of complexes 2 and 3 in compare with 1. The time-dependent fluorescence study, isothermal titration calorimetry (ITC), and circular dichroism (CD) spectral titration provide the additional support to get affirmation about the binding potentiality of the aforementioned complexes with DNA/HSA. The molecular docking study authenticates the experimental approach. Furthermore, the anticancer study of all the complexes has been checked by implementing the MTT assay method on two cancer cell lines and one normal cell line. The MTT assay results explore the better anticancer property of complex 2 in comparison with complexes 1 and 3 with low toxicity to the normal cell, and this fact may be correlated with the impressive DNA and HSA binding efficacy of complex 2.Finally, the nuclear staining study by AO/PI dual sensor discloses the nuclear morphological change of cancer cells along with the opening of cell death mechanism, suggesting the apoptotic pathway.

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Synthesis and crystal structures of Schiff base zinc(III) complexes with antibacterial activity

Cited by 13 publications

References 13 publications

Synthesis, Spectral and Thermal Behavior of Some New Four Coordinated Complexes

Synthesis, Spectral and Thermal Behavior of Some New Four Coordinated Complexes

DNA/HSA binding and anticancer properties of pendant acetate bearing mono-nuclear Ni(ii) and bridging acetate bearing di-nuclear Cu(ii) Schiff base complexes: an experimental and molecular docking study

Development of DNA intercalative, HSA binder pyridine‐based novel Schiff base Cu(II), Ni(II) complexes with effective anticancer property: A combined experimental and theoretical approach

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