Synthesis and crystal structures of <i>N,N'</i>-bis(5-fluoro-2-hydroxybenzylidene)ethane-1,2-diamine and its dinuclear manganese(III) complex with antibacterial activities

Sang, Ya-Li; Li, Xiaochun; Xiao, Wenmin

doi:10.1080/00958972.2013.859253

Cited by 6 publications

(1 citation statement)

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“…We have previously synthesized and characterized different transition metal complexes of salen-type Schiff base ligands, especially those derived from meso-1,2-diphenyl-1,2-ethylenediamine and have studied their catalytic and biological properties [20][21][22][23][24][25][26][27][28][29][30]. In continuation of our previous studies, we report the synthesis and characterization of four new Mn(III) complexes with Schiff bases of general formula [MnClL x ] (x = 1-4).…”

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confidence: 87%

New salen-type manganese(III) Schiff base complexes derived from meso-1,2-diphenyl-1,2-ethylenediamine: In vitro anticancer activity, mechanism of action, and molecular docking studies

Damercheli

Dayyani

Behzad

et al. 2015

Journal of Coordination Chemistry

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Four new manganese(III) Schiff base complexes (1-4) were synthesized and characterized. The complexes have general formula [MnClL x ] in which L represents a Schiff base ligand derived from condensation of meso-1,2-diphenyl-1,2-ethylenediamine with salicylaldehyde or its 3-OMe-, 5-Br-or 5-OMe-derivatives (x = 1-4, respectively). The crystal structure of [MnClL 1 ](1) was characterized by X-ray crystallography. The in vitro anticancer activity of these complexes was evaluated by MTT and apoptosis assays against human breast (MCF-7) and liver (Hep G2) cancer cells. The complexes exhibited considerable antiproliferative activity against both cell lines (IC 50 = 10.8-21.02 µM) comparable to cis-platin, except 4 (MCF-7). The highest activity was found for 1 with IC 50 values of 13.62 µM (MCF-7) and 10.8 µM (Hep G2). Flow cytometry experiments showed that 1 induced apoptosis on MCF-7 tumor cell line. Docking simulations using AUTODOCK were also carried out. The results showed that all complexes fitted into the minor groove region of DNA.

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