Synthesis and Crystal Structure of Novel Benzimidazole Cyclophanes

Abstract

The novel sulfur-containing benzimidazole cyclophanes were synthesized from bis(bromomethyl)benzene (o, m, p) and 2-benzimidazolinthion, respectively. The reaction showed that bromomethyl positions effected the aim compounds very much. It was easy for o-substituted to generate the [1:1] type cyclization product. p-Substituted obtained chain product, and m-substituted benzene pruduced the [2:2] type cyclization compound as main product. The lead compounds were characterized by 1 H NMR, IR, HRMS, and the structure of 1-3a was determined by X-ray diffraction method.