Synthesis and crystal structure of a novel copper(ii) complex of curcumin-type and its application in in vitro and in vivo imaging

Abstract

The results of TPEF imaging in a tumor-bearing mouse model demonstrated the potential of the obtained complex for in vivo tumor diagnosis.

Quantum chemical insights into Alzheimer's disease: Curcumin's chelation with Cu(II), Zn(II), and Pd(II) as a mechanism for its prevention

“…Next, we compare our computed results with various available experimental data on these systems. Both Cu(II) and Zn(II) curcumin complexes with curcumin have been extensively studied by a number of authors . Experimental studies have been focused mostly on synthesizing mononuclear complexes of curcumin with these ions and seeking the effect of chelation on the UV‐visible spectra, IR, and FTIR spectra of these species .…”

“…Transition metal ions such as Cu(II), Zn(II), and Pd(II), have been established as one of the causes of Alzheimer's disease . A primary mechanism is their ability to catalyze polymerization of amyloid‐β and promote further misfolding of amyloid‐β into neurotoxic conformations found in brain cell plaques.…”

“…A primary mechanism is their ability to catalyze polymerization of amyloid‐β and promote further misfolding of amyloid‐β into neurotoxic conformations found in brain cell plaques. Curcumin appears to be a promising candidate as a chelating agent in scavenging these neurotoxic transition metal ions through a competitive chelate complexation mechanism . Moreover, curcumin prevents further misfolding of amyloid‐β into neurotoxic conformations that have been isolated in plaques of brain cells .…”

“…Moreover, metal complexes of curcumin, especially those of ruthenium, palladium, copper, zinc and group(13) elements (Al, Ga, In) exhibit anticancer activity, and thus these metal complexes with curcumin appear to be promising candidates for treatment of certain forms of cancer such as lung cancer cells . Consequently, a number of experimental and a few theoretical studies have been devoted to the study of curcumin's chelation complexes with transition metal ions …”

“…A primary experimental evidence for curcumin's scavenging propensity with these transition metal ions is obtained through spectroscopic techniques . Transition metal ions chelate with curcumin through the loss of an enolic proton of curcumin, where chelation takes place.…”