Synthesis and conformational studies of hyperbranched-core star polymers with poly(γ-benzyl-l-glutamate) arms

Barratt, Claire M.; Haraniya, Tejaswini K.; Iwamasa, Sofie J.; Yun, Justin J.; Desyatkin, Victor G.; Wilcox, Kathryn G.; Morozova, Svetlana A.; Rodionov, Valentin O.

doi:10.1016/j.eurpolymj.2023.111859

Cited by 2 publications

(1 citation statement)

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“…39,40 These efforts aim to enhance control over polymerization, achieve precise molecular weight control, and enable the synthesis of well-defined polypeptide architectures like block copolypeptides and star-shaped polypeptides. 41,42 However, achieving precise control over polymerization kinetics, side reaction management, and stereochemistry control remains complex. 43 Researchers have explored diverse monomers, 44,45 catalysts, 46 reaction conditions 47 to address these challenges.…”

Section: How Can Building Blocks Be Synthesized?mentioning

confidence: 99%

Rational design and engineering of polypeptide/protein vesicles for advanced biological applications

Shin

Jang

2023

J. Mater. Chem. B

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Section: How Can Building Blocks Be Synthesized?mentioning

confidence: 99%

Rational design and engineering of polypeptide/protein vesicles for advanced biological applications

Shin

Jang

2023

J. Mater. Chem. B

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Recent progress of non-linear topological structure polymers: synthesis, and gene delivery

Wang,

He,

Wang

et al. 2024

J Nanobiotechnol

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Currently, many types of non-linear topological structure polymers, such as brush-shaped, star, branched and dendritic structures, have captured much attention in the field of gene delivery and nanomedicine. Compared with linear polymers, non-linear topological structural polymers offer many advantages, including multiple terminal groups, broad and complicated spatial architecture and multi-functionality sites to enhance gene delivery efficiency and targeting capabilities. Nevertheless, the complexity of their synthesis process severely hampers the development and applications of nonlinear topological polymers. This review aims to highlight various synthetic approaches of non-linear topological architecture polymers, including reversible-deactivation radical polymerization (RDRP) including atom-transfer radical polymerization (ATRP), nitroxide-mediated polymerization (NMP), reversible addition-fragmentation chain transfer (RAFT) polymerization, click chemistry reactions and Michael addition, and thoroughly discuss their advantages and disadvantages, as well as analyze their further application potential. Finally, we comprehensively discuss and summarize different non-linear topological structure polymers for genetic materials delivering performance both in vitro and in vivo, which indicated that topological effects and nonlinear topologies play a crucial role in enhancing the transfection performance of polymeric vectors. This review offered a promising guideline for the design and development of novel nonlinear polymers and facilitated the development of a new generation of polymer-based gene vectors.

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Synthesis and conformational studies of hyperbranched-core star polymers with poly(γ-benzyl-l-glutamate) arms

Cited by 2 publications

References 40 publications

Rational design and engineering of polypeptide/protein vesicles for advanced biological applications

Rational design and engineering of polypeptide/protein vesicles for advanced biological applications

Recent progress of non-linear topological structure polymers: synthesis, and gene delivery

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