Synthesis and computational insights of flavone derivatives as potential estrogen receptor alpha (ER-α) antagonist

AutoDock and molecular dynamics-based therapeutic potential prediction of flavonoids for primary Sjögren's syndrome

“…There are over 9000 flavonoids have been identified and grouped into six distinct subclasses according to their basic structure, flavones, flavonols, isoflavones, chalcones, anthocyanidins, and aurones [ 29 , 30 ]. Some kinds of flavonoids have been reported to activate ERα, such as apigenin, naringenin, daidzein, chalcone, and pelargonidin [ [31] , [32] , [33] , [34] ]. However, they belong to different kinds of flavonoids, and their capabilities binding to ERα are unknown [ 35 ].…”