Synthesis and chemical transformations of 1,4‐, 4,1‐, and 1,5‐benzoxazepines

Synthesis and Characterization of New 3‐(3‐Hydroxyphenyl)‐4‐ alkyl‐3,4‐dihydrobenzo[e][1,3]oxazepine‐1,5‐dione Compounds

“…This usually takes place via acylation. 17,18 The N-alkylation of 2,3-dihydro-1,5-benzoxazepin-4(5H)-one type compounds had been reported. [19][20][21] Our interest in [1,3]oxazepine-4,7-dione molecules arise from our earlier observation of other heterocyclic molecules which have liquid crystalline properties.…”

Enantioselective Formal [4 + 3] Annulations to Access Benzodiazepinones and Benzoxazepinones via NHC/Ir/Urea Catalysis

“…Rocastine ( III ) shows potent antihistaminic activity, and more importantly, its optical isomers with a stereodefined chiral Csp at C-2 show marked differences in the antihistaminic potency . Consequently, the interest associated with the pharmacological activities of 1,4-benzodiazepine and 1,4-benzoxazepine scaffolds justifies a continuation of the work on efficient synthetic methods, and the catalytic enantioselective synthesis of these seven-membered heterocycles remains yet to be discovered …”