Synthesis and chemical properties of cyclic β-keto sulfones (review)

Boosting Sulfonylation Reactions between Vinyl Triflates and Alkenes toward β-Ketosulfones Using Aqueous Sulfurous Acid

“…This is presumably due to the fast addition of alkyl radical C to vinyl triflates that contain an electron-withdrawing group to give radical F due to polarity matching, resulting in lower yields of the corresponding β-ketosulfone. To expand the scope of this reaction and considering the importance of β-ketosulfones in synthetic and medicinal chemistry, 14 15 16 we report herein the synthesis of trifluoromethylated β-ketosulfones 5 from vinyl triflates that contain an electron-withdrawing group and alkenes using sulfurous acid (H 2 SO 3 ) as an external source of SO 2 (Scheme 1 , eq. 3).…”

Synthesis of α‐Sulfonyl Ketones through a Salicylic Acid‐Catalyzed Multicomponent Reaction Involving Arylsulfonation and Oxidation

“…[4] In chemistry, α-sulfonyl ketones are versatile synthons in organic synthesis. [5][6][7] For examples, they have found applications in the synthesis of substituted alkenes, [8] alkynes, [9,10] and allenes, [11] 4H-pyrans, [12] β-hydroxysulfones, [13,14] vinylsulfones, [14] ketones, [15] and carboxylic acids. [16] Because of their broad utility in synthetic and medicinal chemistry, many synthetic methods have been developed for the preparation of α-sulfonyl ketones.…”

{Mo132} Nanoball as an Efficient and Cost-Effective Catalyst for Sustainable Oxidation of Sulfides and Olefins with Hydrogen Peroxide

“…Selective oxyfunctionalization of organic compounds is a pivotal reaction in many organic syntheses of biologically active molecules such as sulfoxides, sulfones, and epoxides . The long-standing interest in the sulfoxidation of organic sulfides is primarily fueled by its utility in diverse areas of chemistry originating from the constant use of sulfoxides-derived chiral auxiliaries in total synthesis − to its use in medicinal chemistry − and biology to its application in industrially important desulfurization processes. − Moreover, overoxidation of sulfoxides generates sulfone products that exhibit different biological activities and have been the subject of extensive investigation. − Epoxides are also industrially important chemicals that are produced at scales ranging from millions of tons to a few grams per year. They are widely used as intermediates for several perfumery chemicals, plasticizers, and sweeteners. , …”