Synthesis and Characterizations of Keplerate Nanocapsules Incorporating L- and D-Tartrate Ligands

Awada, Mouhamad; Floquet, Sébastien; Marrot, Jérôme; Haouas, Mohamed; Morcillo, Sara P.; Bour, Christophe; Gandon, Vincent; Coeffard, Vincent; Greck, Christine; Cadot, Emmanuel

doi:10.1007/s10876-017-1171-7

Cited by 9 publications

(7 citation statements)

References 44 publications

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“…Figure shows the structural features of these building units. Crystalline form of {Mo 132 } derivatives have been characterized by X‐ray diffraction and only very recently by 1 H solid state NMR . Here, we were able to record 95 Mo NMR spectra of the Keplerate {Mo 132 }, difficult to observe by liquid‐state NMR, probably because its large molecular size reduces the Brownian motion and induces too short T 2 values.…”

Section: Resultsmentioning

confidence: 99%

High‐field ⁹⁵Mo and ¹⁸³W static and MAS NMR study of polyoxometalates

Haouas

Trébosc

Roch‐Marchal

et al. 2017

Magnetic Reson in Chemistry

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The potential of high-field NMR to measure solid-state Mo and W NMR in polyoxometalates (POMs) is explored using some archetypical structures like Lindqvist, Keggin and Dawson as model compounds that are well characterized in solution. NMR spectra in static and under magic angle spinning (MAS) were obtained, and their analysis allowed extraction of the NMR parameters, including chemical shift anisotropy and quadrupolar coupling parameters. Despite the inherent difficulties of measurement in solid state of these low-gamma NMR nuclei, due mainly to the low spectral resolution and poor signal-to-noise ratio, the observed global trends compare well with the solution-state NMR data. This would open an avenue for application of solid-state NMR to POMs, especially when liquid-state NMR is not possible, e.g., for poorly soluble or unstable compounds in solution, and for giant molecules with slow tumbling motion. This is the case of Keplerate where we provide here the first NMR characterization of this class of POMs in the solid state. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

High‐field ⁹⁵Mo and ¹⁸³W static and MAS NMR study of polyoxometalates

Haouas

Trébosc

Roch‐Marchal

et al. 2017

Magnetic Reson in Chemistry

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“…This difficulty in resolving ligands beyond the carboxylate moiety within the {Mo 132 }‐framework is well known and is found in many previously reported crystal structures. [ 21 , 22 ] Due to the high symmetry of the Mo framework ( I h ), all structures crystallise in the R ‐3 centrosymmetric space group, rather than a chiral space group.…”

Section: Resultsmentioning

confidence: 99%

Enantioselective Recognition of Racemic Amino Alcohols in Aqueous Solution by Chiral Metal‐Oxide Keplerate {Mo₁₃₂} Cluster Capsules

Pow

Sinclair

Bell

et al. 2021

Chemistry A European J

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Determining the relative configuration or enantiomeric excess of a substance may be achieved using NMR spectroscopy by employing chiral shift reagents (CSRs). Such reagents interact noncovalently with the chiral solute, resulting in each chiral form experiencing different magnetic anisotropy; this is then reflected in their NMR spectra. The Keplerate polyoxometalate (POM) is a molybdenum-based, water-soluble, discrete inorganic structure with a poreaccessible inner cavity, decorated by differentiable ligands. Through ligand exchange from the self-assembled nano-structure, a set of chiral Keplerate host molecules has been synthesised. By exploiting the interactions of analyte molecules at the surface pores, the relative configuration of chiral amino alcohol guests (phenylalaninol and 2-amino-1-phenylethanol) in aqueous solvent was establish and their enantiomeric excess was determined by 1 H NMR using shifts of ΔΔδ = 0.06 ppm. The use of POMs as chiral shift reagents represents an application of a class that is yet to be well established and opens avenues into aqueous host-guest chemistry with self-assembled recognition agents.

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“…In addition, it was shown that simpler molybdenum-containing POMs can be used in chemotherapy [115,116]. On the other hand, the initially predicted possibility of the formation of POM conjugates with bioactive substances, drugs, and metal cations using intra-and extrasphere interactions, the possibility of their transport (including iontophoretic) in the body, adds relevance to the studies of POM in the field of targeted drug delivery and diagnostics [117][118][119][120][121][122][123][124][125][126][127][128][129][130][131]. These prospects may relate, inter alia, to immunomodulatory and antiviral agents.…”

Section: Nanocluster Polyoxometalates (Poms)mentioning

confidence: 99%

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

Ostroushko¹,

Grzhegorzhevskii²,

Medvedeva³

et al. 2021

Nanosystems: Phys. Chem. Math.

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The paper discusses the results of a research on physicochemical and biochemical properties of the Keplerate-type molybdenum-based nanocluster polyoxometalates (POMs), which show promise in the field of biomedicine as a means of targeted drug delivery, including the transport to immune privileged organs. POMs can be considered as components of releasing systems, including the long-acting ones with feedback (for controlling the drug active component release rate). POMs are promising drugs for the treatment of anemia. Also, the paper deals with the results of studies of POM effect on living systems at the molecular and cellular levels, at that of individual organs, and on the organism as a whole. The mechanism and kinetics of POM destruction and possibilities of stabilization, the oscillatory phenomena manifestation, the formation of POM conjugates with bioactive substances which can be released during the destruction of POM, with polymer components, and with indicator fluorescent dyes, as well as forecasts for further research, are considered.

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Synthesis and Characterizations of Keplerate Nanocapsules Incorporating L- and D-Tartrate Ligands

Cited by 9 publications

References 44 publications

High‐field ⁹⁵Mo and ¹⁸³W static and MAS NMR study of polyoxometalates

High‐field ⁹⁵Mo and ¹⁸³W static and MAS NMR study of polyoxometalates

Enantioselective Recognition of Racemic Amino Alcohols in Aqueous Solution by Chiral Metal‐Oxide Keplerate {Mo₁₃₂} Cluster Capsules

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

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Synthesis and Characterizations of Keplerate Nanocapsules Incorporating L- and D-Tartrate Ligands

Cited by 9 publications

References 44 publications

High‐field 95Mo and 183W static and MAS NMR study of polyoxometalates

High‐field 95Mo and 183W static and MAS NMR study of polyoxometalates

Enantioselective Recognition of Racemic Amino Alcohols in Aqueous Solution by Chiral Metal‐Oxide Keplerate {Mo132} Cluster Capsules

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

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Product

Resources

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High‐field ⁹⁵Mo and ¹⁸³W static and MAS NMR study of polyoxometalates

High‐field ⁹⁵Mo and ¹⁸³W static and MAS NMR study of polyoxometalates

Enantioselective Recognition of Racemic Amino Alcohols in Aqueous Solution by Chiral Metal‐Oxide Keplerate {Mo₁₃₂} Cluster Capsules