Synthesis and Characterization of Various Alkyl, Aryl and Hetero Aryl Substituted Hydrazines and Study of their Biological Activity

Abstract

Due to the presence of N-N linkage hydrazines are well-known for their diverse biological activity.N-N linkage has been used as a key structural motif in various bioactive agents. A series of aryl, alkyl and hetero aryl substituted hydrazine derivatives has been synthesized, for this diazotization of alkyl, aryl amines has been done, followed by reduction with stannous chloride or sodium sulfite. All synthesized compounds were characterized by elemental analysis, IR, 1H-NMR, Mass spectra and their biological activity has been studied.

Design, DFT Calculations and Antimicrobial Activity of New Synthesized Piperazine Derivative

“…The imine group (azomethine) of Schiff bases attracted much attention due to widely usage in biological studies and which was use in chemistry (Venkataramana et al, 2010;Yan et al, 2012;Gupta & Goklani, 2017;Ermiş & Durmuş, 2020). Piperazine ring is also an important class of N-heterocyclics having biological activities including antitumor (Xu et al, 2019), antiviral drugs (Hooshmand et al, 2021), antibacterial (Jalagari et al, 2019) and antifungal etc (Suryavanshi & Rathore, 2017) and pharmaceutical applications (Ullh et al, 2022).…”