Synthesis and Characterization of Two Chiral Pyrrolyl α-Nitronyl Nitroxide Radicals and Determination of their Cytotoxicity and Radioprotective Properties in C6 Cells and Mice under Ionizing Radiation
Abstract:In this study, two chiral nitronyl nitroxyl radicals, L1 and D1, were synthesized and evaluated for their potential radioprotective properties invitro and invivo. We synthesized the new stable nitronyl nitroxide radicals, L1 and D1, according to Ullman’s method, and their chemical structures were characterized using UV-vis absorption, electron spin resonance (ESR), and circular dichroism (CD) spectra. The cytotoxicity of L1 and D1 on C6 glioma cells (C6 cells) was examined using the MTT (3-(4,5-dimethylthiazol… Show more
The synthesis, structures and magnetic properties of an unprecedented P-stereogenic phosphinic amide-4-amino-TEMPO radical and its Cu(hfac)2 complex are reported.
The synthesis, structures and magnetic properties of an unprecedented P-stereogenic phosphinic amide-4-amino-TEMPO radical and its Cu(hfac)2 complex are reported.
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