Synthesis and characterization of thiolated alginate-albumin nanoparticles stabilized by disulfide bonds. Evaluation as drug delivery systems

Martı́nez, Ana M.; Iglesias, I.; Lozano, Raquel García; Teijón, José M.; Blanco, Marcos

doi:10.1016/j.carbpol.2010.09.038

Cited by 66 publications

(42 citation statements)

References 31 publications

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“…In vitro studies revealed that total release of the drug was not achieved in any case; only the 23-61% of the drug was released. Maximum release took place between 7 and 75 h. According to the results, it was concluded that the presence of alginate in the nanoparticle composition allowed the modulation of the amount of released TMX (Martínez et al, 2011).…”

Section: Anticancer Drugs Included In Polysaccharide-based Delivery Smentioning

confidence: 88%

“…Recently, nanoparticles based on thiolated alginate and modified albumin have been synthesized and stabilized by the formation of disulphide bonds between both polymers (Martínez et al, 2011). In this case, the covalent interaction is established between the sulfhydryl groups of the albumin, obtained after a reduction process of the protein, and the sulfhydryl groups of the L-cysteine which has been attached to the polysaccharide structure using a carbodiimide reaction.…”

Section: Polysaccharide-based Nanoparticles With Covalent Cross-linksmentioning

confidence: 99%

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Polysaccharide-Based Nanoparticles for Controlled Release Formulations

Martı́nez¹,

Fernandez²,

Pérez³

et al. 2012

The Delivery of Nanoparticles

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Section: Anticancer Drugs Included In Polysaccharide-based Delivery Smentioning

confidence: 88%

Section: Polysaccharide-based Nanoparticles With Covalent Cross-linksmentioning

confidence: 99%

Polysaccharide-Based Nanoparticles for Controlled Release Formulations

Martı́nez¹,

Fernandez²,

Pérez³

et al. 2012

The Delivery of Nanoparticles

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“…All our release data showed good correlation with Zero order kinetics, therefore, liposomal nanoparticles could be used as an ideal carrier for the delivery of GTP, achieving a prolonged or a sustained release. Korsmeyer-Peppas stated that for a Fickian release, n value is constrained to 0.5, 0.45, and 0.43 for the release from slabs, cylinders, and spheres (26). For spheres, values of n ranging from 0.43-0.89 are regarded as anomalous and the release is characterized by diff usion and erosion mechanism and that > 0.89 is characterized by the polymer erosion and relaxation and is termed as super case II transport.…”

Section: Discussionmentioning

confidence: 99%

Sustained Release of Green Tea Polyphenols from Liposomal Nanoparticles; Release Kinetics and Mathematical Modelling

Upputuri

Mandal

2017

Iran. J. Biotechnol.

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Background: Green tea polyphenols (GTP) are known to have several health benefi ts. In spite of these benefi ts, its application as a therapeutic agent is limited due to some of its limitations such as stability, bioavailability, and biotransformation. To overcome these limitations, liposomal nanoparticles have been used as a carrier of the GTP. Objective: Encapsulation of GTP to the liposomal nanoparticles in order to achieve a sustained release of the GTP and to determine the drug release kinetics and the mechanism of the release. Materials and Methods: GTP encapsulated liposomal nanoparticles were prepared using phosphatidyl choline and cholesterol. The synthesized particles were characterized for their particle size and morphology. In vitro release studies were carried out, followed by drug release kinetics, and determining the mechanism of release. In vitro, antioxidant assay was determined following 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Results: Atomic force microscope (AFM) and high resolution scanning electron microscope (HR SEM) images showed spherical particles of the size of 64.5 and 252 nm. An encapsulation effi ciency as high as 77.7% was observed with GTP concentration of 5 mg.mL -1 . In vitro release studies showed that the loading concentrations of GTP were independent to the cumulative percentage of the drug release. GTP release by varying the pH and temperature showed a direct correlation between the release parameter and the percentage of drug release. The higher the pH and temperature, the higher was the percentage of the drug release. The release data showed a good correlation with Zero order kinetics and the mechanism of the release being anomalous mode. Radical scavenging activity of the released GTP showed a potent scavenging activity. Conclusion: GTP encapsulated liposomal nanoparticles could be used as a delivery vehicle for achieving a sustained release.

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“…Drug molecules are commonly distributed into the gelispheres to form a three-dimensional lattice of ionically cross-linked moiety before the drug-loaded nanoparticles are generated 10 . Studies on alginate-nanoparticle materials have increased greatly over the past decade [11][12][13][14][15] . β-Cyclodextrin (β-CD) is a cyclic oligosaccharide consisting of seven (α-1,4)-linked α-D-glucopyranose units as shown in Fig.…”

Section: +mentioning

confidence: 99%

Synthesis and Characterization of β-Cyclodextrin/alginate Nanoparticle as a Novel Drug Delivery System

Nguyen¹,

Tran

Nguyen

et al. 2015

Chem. Biochem. Eng. Q.

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The aim of this work was to study a novel nanoparticle system formed from alginate and β-cyclodextrin by ionotropic gelation method and to evaluate their potential for the association and delivery of drugs. The nanoparticles were prepared by electrostatic interactions between Ca 2+ /alginate gel and β-cyclodextrin. Morphology and structure characterization of nanoparticles was investigated by scanning electron micrographs (SEM), transmission electron microscope (TEM), Fourier transform infrared spectra (FTIR). The nanoparticle size was about 50 -80 nm and their structure quite regular and consistent. Ketoprofen, chosen as a model drug, was incorporated into the nanocarriers with association efficiency of 50.7 % and loading efficiency of 5.7 %. Ketoprofen released from the nanoparticles was 57 % at pH 7.4 and 69 % at pH 5.0 for 4 h.

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Synthesis and characterization of thiolated alginate-albumin nanoparticles stabilized by disulfide bonds. Evaluation as drug delivery systems

Cited by 66 publications

References 31 publications

Polysaccharide-Based Nanoparticles for Controlled Release Formulations

Polysaccharide-Based Nanoparticles for Controlled Release Formulations

Sustained Release of Green Tea Polyphenols from Liposomal Nanoparticles; Release Kinetics and Mathematical Modelling

Synthesis and Characterization of β-Cyclodextrin/alginate Nanoparticle as a Novel Drug Delivery System

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