Synthesis and Characterization of Thieno[2,3-d]pyrimidin-4-ol Tethered with 1,2,3-Triazole Derivatives and Their Antimicrobial Activity

Abstract

In effort to develop biologically active compounds, novel heterocyclic compounds of thieno[2,3-d]pyrimidine tethered with 1,4-disubstituted-1,2,3-triazoles through methylene-oxy group were synthesized and characterized. The synthesized technique possesses a number of standout characteristics, including few reaction steps, high yield, simple reaction conditions and no need for any further purification processes. The in vitro antimicrobial efficacy of the synthesized derivatives was evaluated and several compounds were found to be moderate to excellent inhibition.