Synthesis and Characterization of Thermally Stable and Biologically Active Metal-Based Schiff Base Polymer

Abstract

Schiff base was prepared via condensation of ethanedihydrazide with 2-hydroxy benzaldehyde and further this monomeric Schiff base polymerize with formaldehyde and barbituric acid and form polymeric Schiff base (PLSB) ligand. The ligand and its polymer metal complexes were characterized by using elemental analysis, IR, UV-VIS, 1 HNMR, magnetic susceptibility and thermogravimetric studies. On basis of elemental analysis and spectral studies, six coordinated geometry was assigned for Mn(II), Co(II) and Ni(II) complexes and four coordinated for Cu(II) and Zn(II) complexes. PLSB act as a tetradentate and coordinate through the azomethine nitrogen and phenolic oxygen. The thermal behavior of these polymer metal complexes showed that the hydrated complexes losses water molecules of hydration in the first step followed immediately by decomposition of the anions and ligand molecules in the subsequent steps. The (PLSB) ligands and its polymer metal complexes were screened against bacterial species Escherichia coli, Staphylococcus aureus, Bacillus subtilis and fungal species Aspergillus flavus, Candida albicans, A. niger. The activity data show that the metal complexes were more potent than the parent Schiff bases.

Metal-containing and related polymers for biomedical applications

“…Main-chain polymeric Schiff bases were prepared through a condensation reaction. 92 Then, the target metal-containing polymer can be prepared in quantitative yields by interacting with an equimolar amount of transition metal salts (Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)). Compared with the polymeric Schiff bases, Parveen et al found that all of these metalcontaining polymeric compounds showed enhanced antibacterial activity against E. coli, B. subtilis, S. aureus, P. aeruginosa and S. typhi, and antifungal activity against T. longifusus, C. albicans, M. canis, F. solani and C. glaberata.…”

“…They attributed the enhanced activity to the coordination interaction with metal ions. 92,93 Germanium and its derivatives have been utilized for dietary supplements, immunity enhancement and antimicrobial materials. [94][95][96] Based on their unique properties, germaniumcontaining polymers were also investigated.…”

Synthesis and Characterization of Linear Thermally Stable polyester contain Schiff Bases

“…They are synthesized by polycondensation reaction between diamine and dialdehyde or diketone [10]. They are an important category of compounds and useful complexing ligands for a number of transition metal ions and indicate paramagnetism, semiconducting and resistance to high energy [11,12]. They are used to prepare composite materials having high resistance at high temperatures, thermostabilized, photoresistors, flame resistance materials, and components of electrochemical cells.…”

Synthesis, Characterization and Biological Studies of New Linear Thermally Stable Schiff Base Polymers with Flexible Spacers

“…6,7 They are an important class of compounds and find their application in different fields. They are useful complexing ligands for a number of transition metal ions 8,9 and indicate paramagnetism, semiconducting and resistance to high energy. [10][11][12][13] They are used to prepare composite materials having high resistance at high temperatures, thermostablizers, photoresistors, flame resistance materials, and components of electrochemical cells.…”