Synthesis and characterization of tannic acid–PEG hydrogel via Mitsunobu polymerization

Abstract

Mitsunobu polymerization was involved to construct bulk hydrogel via direct PEGylation of tannic-acid under mild condition.

Tannic acid: a crosslinker leading to versatile functional polymeric networks: a review

“…12 ). 122 This phenol–alcohol reaction was conducted under mild conditions (0–25 °C) in the presence of PPh 3 /diisopropyl azodicarboxylate (DIAD). TA–PEG hydrogel could not only chelate Fe III to form a composite hydrogel, but also had the ability to reduce Au III and Ag I ions rapidly within 5–10 min to produce the corresponding nanoparticles.…”

Injectable reactive oxygen and nitrogen species-controlling hydrogels for tissue regeneration: current status and future perspectives

“…Similar to gallic acid, TA and EGCG have gained significant attention for their excellent biological properties, such as antioxidant, free radical scavenging, anti-inflammatory and antibacterial activities [ 57 , 58 ]. In recent years, TA and EGCG have been widely used as ideal crosslinkers for in situ formation of hydrogels, owing to their ability to complex or crosslink macromolecules at multibinding sites through hydrogen/ionic bonding and hydrophobic interactions [ 59 ]. In particular, beside antioxidant property, the resulting hydrogels exhibit multiple functionalities, including adhesiveness, self-healing, antibacterial, anti-inflammatory and degradation resistance.…”

Antibacterial, wearable, transparent tannic acid–thioctic acid–phytic acid hydrogel for adhesive bandages

“…40 Coincidently, poly(organosulfur) derived from thioctic acid can act as a spacer as well as a covalent binder for polyphenols. (ii) The combination between polyphenols and poly(organosulfur) is beneficial for integrating the advantages of antimicrobial, 41 antioxidant, 42 reductive, 43 self-healing, 44 optical 45 and electrochemical properties; 46 (iii) these hybrid hydrogels could be easily prepared under mild conditions, following the rule of green chemistry. Chai et al reported a novel hydrogel using dopamine and thioctic acid with a strong tissue adhesion force.…”