Synthesis and characterization of surface-cyanofunctionalized poly ( N -isopropylacrylamide) latexes

Zhou, Guangyuan; Elaissari, Abdul Hamid; Delair, Th.; Pichot, C.

doi:10.1007/s003960050355

Cited by 32 publications

(24 citation statements)

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“…1, 2, 5, 7 Monodispersed nanogels over a wide range of sizes have been synthesized by a number of different methods, 13, 18, 19 with free-radical precipitation polymerization being the most common. 7,18,[20][21][22][23][24] Perhaps the most interesting behavior of pNIPAm nanogels is the swelling/deswelling of the gels in water upon reaching the lower critical solution temperature (LCST), which occurs around 31 °C. Below this temperature, the particles are hydrophilic and swollen.…”

Section: Introductionmentioning

confidence: 99%

Size-controlled synthesis of monodisperse core/shell nanogels

2007

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Small, monodispersed nanogels (~ 50-nm radius) were synthesized by free-radical precipitation polymerization and characterized using a suite of light scattering and chromatography methods. Nanogels were synthesized with either N-isopropylacrylamide or N-isopropylmethacrylamide as the main monomer, with acrylic acid or 4-acrylamidofluorescein as a co-monomer and N, N′-methylenebis(acrylamide) as a cross-linker. By varying the surfactant and initiator concentrations, particle size was controlled while maintaining excellent monodispersity. An amine-containing shell was added to these core particles to facilitate subsequent bioconjugation. Successful conjugation of folic acid to the particles was demonstrated as an example of how such materials might be employed in a targeted drug delivery system.

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Section: Introductionmentioning

confidence: 99%

Size-controlled synthesis of monodisperse core/shell nanogels

2007

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“…Furthermore, chemical modification can introduce functional groups into the thermo-sensitive microgels that might allow for selective recognition for certain molecules and further modification of the microgels. There have been some reports on the chemical modification of pNIPAM [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Flocculation behavior of temperature-sensitive poly(N-isopropylacrylamide) microgels containing polar side chains with OH groups

Tang

2006

Journal of Colloid and Interface Science

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“…[15–18] Alternatively, one can impart the nanogel surface with chemical handles for covalent attachment of functionalities in the post-polymerization stage. [19–23] In order to design complex and versatile nanogels, it is often desired that the particle have multiple different chemical handles. However, in many cases chemoligations that can be carried out on nanoparticles are complicated and even prohibited by the presence of interfering functional groups.…”

Section: Introductionmentioning

confidence: 99%

“…[27, 28] A number of synthetic strategies have been developed for the production of pNIPAm nanogels. [22, 23, 29–35] Interesting architectures such as core/shell nanoparticles have been synthesized via two-stage precipitation polymerization, which offers the ability to spatially localize chemical functionalities to a defined position, to render thermoresponsivity to non-responsive particles, or to modify specific physical properties of the nanoparticles. [14, 29, 36] As argued above, the integration of multiple functional groups onto these thermosensitive nanoparticles is required to explore a range of applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of multifunctional nanogels using a protected macromonomer approach

Singh

Lyon

2008

Colloid Polym Sci

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Nanoparticles possessing multiple functionalities provide synthetic handles for varied surface chemistries, making them useful for a range of applications such as biotargeting and drug delivery. However, the combination of interfering functionalities on the same particle is often challenging. We have employed a synthetic scheme involving chemical protection/deprotection to combine interfering functional groups on the same hydrogel nanoparticle. The synthesis of amine-containing poly(N-isopropylacrylamide) nanogels was carried out via free radical precipitation polymerization by incorporating a Fmoc-protected amine PEG macromonomer. The Fmoc group was then removed to obtain free amines, which were shown to be available for conjugation. We further explored pNIPAm-co-acrylic acid nanogels with a protected amine-PEG, yielding zwitterionic particles. With careful attention to the order of the chemoligation and deprotection steps, these interfering functional groups can be forced to behave in a pseudo-orthogonal fashion, allowing for multiple chemoligation steps that employ both the amine and carboxylic acid groups.

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Synthesis and characterization of surface-cyanofunctionalized poly ( N -isopropylacrylamide) latexes

Cited by 32 publications

References 0 publications

Size-controlled synthesis of monodisperse core/shell nanogels

Size-controlled synthesis of monodisperse core/shell nanogels

Flocculation behavior of temperature-sensitive poly(N-isopropylacrylamide) microgels containing polar side chains with OH groups

Synthesis of multifunctional nanogels using a protected macromonomer approach

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