Abstract:The 1,3-dipolar cycloaddition reaction is a three-component reaction used for the synthesis of structurally complex and biologically active spiro-heterocycles. In the present work a two steps synthesis of the target compounds (7-22) are presented. 2-acetyl phenothiazine was converted into a chalcone 1 which was treated with various azomethine ylides to yield the compounds 7-22. The diversity in the azomethine ylides was made by using a variety of diones 2a-2d and the different aminoacids 3-6. The anti-cancer a… Show more
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