Synthesis and Characterization of Spherical Magnetite/Biodegradable Polymer Composite Particles

Gómez-Lopera, S.A.; Plaza, R.C.; Delgado, A.V.

doi:10.1006/jcis.2001.7579

Cited by 211 publications

(127 citation statements)

References 30 publications

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“…These findings are in agreement with previous determinations described previously [13,20] who have been working with iron oxide-PLGA composite particles. The electrokinetic properties of Mag loaded PCL nanocapsules are in agreement with those of pure PCL, as one would predict in case of an optimum coverage [41].…”

supporting

confidence: 80%

Superparamagnetic maghemite loaded poly (ε- caprolactone) nanocapsules : characterization and synthesis optimization

et al. 2014

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Iron oxide nanoparticles (ION) have been studied for essential applications, like detection of biological constituents (virus, bacterials, cell, nucleic acids, protein, enzyme, etc.), magnetic bioseparation and clinic therapy and diagnosis (such as MRI magnetic fluid and hyperthermia). In this work, γ-Fe 2 O 3 has been synthetized by a adapted sol-gel method and entraped in poly ε-caprolactone (PCL) nanocapsules. The superparamagnetic nanocapsules have been formulated by double emulsion evaporation method. Some variables affecting the polydispersity index, zeta potential surface and size of nanocapsules were studied aiming optimize the formulation process of maghemite-loaded PCL nanocapsules. The following parameters were selected: sonication time, PCL concentration in organic phase, PVA concentration in external aqueous phase and maghemite/PCL weight ratio. Under these experimental conditions, the resulting nanocapsules displayed a mean size of about 346 nm and a maghemite content of about 7.5 µg/mg of nanocapsules and superparamagnetic behaviour at room temperature.

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confidence: 80%

Superparamagnetic maghemite loaded poly (ε- caprolactone) nanocapsules : characterization and synthesis optimization

et al. 2014

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“…[304] Furthermore, subsequent formation of reactive oxygen species (ROS) will result in loss of magnetic properties of oxidized MNPs on one hand, in a decrease of their biocompatibility on the other hand. [305] Although, magnetite (Fe 3 O 4 ) nanoparticles are highly magnetizable and resistant to oxidation, a loss in their magnetism properties occur once they are oxidized and convert into hematite nanoparticles. [306] Hence, coating is a major determinant of MNPs stability to protect them from oxidation and corrosion in ambient conditions.…”

Section: Exigencies Of Coatings Mnpsmentioning

confidence: 99%

“…[81] However, use of nonmagnetic coating will also decrease the magnetic saturation of MNPs. [305] Most importantly, coatings should provide functional groups (e.g., amine, carboxyl groups) for accommodating therapeutics, targeting ligands, and reporter moieties as an important step that assists labeling specificity of MNPs toward different applications. [302a] Type of coating is very close to biocompatibility and blood circulation time of MNPs, as it will be described in design considerations section.…”

Section: Exigencies Of Coatings Mnpsmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

182

164

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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“…Composite particles with a size of 180 nm were produced from preformed poly(D,L-lactide) polymer. 141 However, usually the particle size obtained by the double-emulsion technique ranges from 100 nm to 2 lm with a broad size distribution. Aggregation of magnetite particles makes it difficult to prepare individual polymercovered magnetite units.…”

Section: Magnetite As Markermentioning

confidence: 99%

From polymeric particles to multifunctional nanocapsules for biomedical applications using the miniemulsion process

Landfester

Musyanovych

Mailänder

2009

J. Polym. Sci. A Polym. Chem.

160

122

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ABSTRACT:The miniemulsions process represents a versatile tool for the formation of polymeric nanoparticles consisting of different kinds of polymer as obtained by a variety of polymerization types ranging from radical, anionic, cationic, enzymatic polymerization to polyaddition, and polycondensation. The process perfectly allows the encapsulation of hydrophilic and hydrophobic liquids and solids in polymeric shells, molecularly dissolved dyes or other components. In combination with a specific functionalization of the nanoparticles' or nanocapsules' surfaces and the possibility to release substances in a defined way from the interior, complex nanoparticles or nanocapsules are obtained, which are ideally suited for application in biomedical application as marker and targeted drug-delivery system. V C 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 2010

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Synthesis and Characterization of Spherical Magnetite/Biodegradable Polymer Composite Particles

Cited by 211 publications

References 30 publications

Superparamagnetic maghemite loaded poly (ε- caprolactone) nanocapsules : characterization and synthesis optimization

Superparamagnetic maghemite loaded poly (ε- caprolactone) nanocapsules : characterization and synthesis optimization

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

From polymeric particles to multifunctional nanocapsules for biomedical applications using the miniemulsion process

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