Synthesis and Characterization of Some New Nitrones Derivatives and Screening their Biological Activities

Abstract

Synthetic approached towards the synthesis of some novel nitrones derivatives have been started with reduction of nitrobenzene derivatives as starting material bearing electron withdrawing and electron donating groups to corresponding phenylhydroxylamine in presence of zinc dust as reducing agent in aqueous solution of ammonium chloride (NH4Cl). The prepared phenylhydroxylamine derivatives were reacted with different substituted benzaldehydes to give the target derivatives of nitrone. The structures of the synthesized nitrones were characterized by spectroscopic methods FT-IR, 1H-NMR and 13C NMR. Finally the newly synthesized compounds were screened for their microorganism activities at different concentration, and inhibited growth of Escherichia coli (E. coli) Gram negative, Staphylococcus aureus (S. aureus) Gram positive, and fungi (candida albicans).

Construction of Crystalline Nitrone-Linked Covalent Organic Frameworks Via Kröhnke Oxidation

“…From the FT-IR spectra (Figure b, Figure S1), the absorption bands in BPS belonging to pyridine moieties (3045 and 1634 cm –1 ), methylene (2939 and 2837 cm –1 ), and C–N stretching vibration (1122 cm –1 in TBP-3NO, 1113 cm –1 in TPBP-3NO) vanished or were remarkably attenuated after the polycondensation, implying the occurrence of reactions. In contrast, the characteristic signals at ∼1078 cm –1 for CityU-1 and ∼1096 cm –1 for CityU-2 arising from the + N–O – of nitrones were observed. ,− It is noted that another characteristic signal (∼1600 cm –1 ), belonging to CN + stretching of nitrone bonds, was not discernible on account of the overlapping with those of aromatic rings . Clearly, all these variations were consistent with the features in the model compound while strikingly differentiating from the reported imine-based analogues, confirming the existence of nitrone linkages in as-synthesized COFs.…”

Synthesis of Some novel Azomethine Oxide Derived from Aromatic Oximes and their Anti-microbial Studies

“…The resulting products can have interesting biological activities and can serve as building blocks for the synthesis of more complex molecules (Anderson, et al, 2016). Nitrones are widely used in the synthesis of natural products, pharmaceuticals, and other biologically active compounds (Mohammed and Salih, 2022). They have been employed in the development of drugs for various therapeutic areas, including neurodegenerative diseases, cancer, antimicrobial, antitumor, anti-inflammatory properties, and infectious diseases (Yang, et al, 2017;McKay, et al, 2011;Sandmeier and Carreira, 2021).…”