Synthesis and characterization of some cellulose/chondroitin sulphate hydrogels and their evaluation as carriers for drug delivery

Oprea, Ana-Maria; Profire, Lenuța; Lupușoru, Cătălina Elena; Ghiciuc, Cristina Mihaela; Ciolacu, Diana; Vasile, Cornelia

doi:10.1016/j.carbpol.2011.08.052

Cited by 35 publications

(20 citation statements)

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“…In the same time, this polysaccharide is not degradable in the body and is not digestible due to the fact that human and animal cells do not synthesize cellulases, the enzymes capable of degrading cellulose [25]. All these properties made the cellulose hydrogels suitable for various applications, especially in the biomedical field [26][27][28].…”

Section: Introductionmentioning

confidence: 97%

Synthesis and characterization of polyvinyl alcohol/cellulose cryogels and their testing as carriers for a bioactive component

Paduraru

Ciolacu

Darie

et al. 2012

Materials Science and Engineering: C

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Section: Introductionmentioning

confidence: 97%

Synthesis and characterization of polyvinyl alcohol/cellulose cryogels and their testing as carriers for a bioactive component

Paduraru

Ciolacu

Darie

et al. 2012

Materials Science and Engineering: C

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“…Cellulose/chondroitin sulfate (CS) hydrogels were also prepared with esterification crosslinking and used for drug delivery. The drug loading efficiency was up to 92.5% and a retarded release of the loaded drug was controlled by the CS content in the hydrogels …”

Section: Chemical Crosslinked Cellulose‐based Gelsmentioning

confidence: 99%

Cellulose-Based Gels

Kang

Liu

Huang

2016

Macromol. Chem. Phys.

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Cellulose is the most available biomacromolecule in nature with the properties of renewability, biodegradability, biocompatibility, and environmental friendliness. Cellulose and its derivatives are excellent building blocks for fabrication of gels. In this review, the principles for preparing cellulose‐based gels are summarized in detail. Considering the native properties of cellulose and its derivatives, chemical and/or physical crosslinking can be introduced during the preparation of cellulose‐based gels. The chemical and physical crosslinking approaches are classified alongside the introduction of new concepts in polymer science, such as supramolecular interactions. Cellulose graft copolymers are another kind of building block in the fabrication of cellulose‐based gels. The properties of gels can be tailored by the chemical structure of the graft chains. Cellulose‐based gels can be applied in many fields depending on their properties.

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“…Oprea and colleagues studies (130,131) described the synthesis of cellulose/CS-based hydrogels for their use as drug delivery systems by a chemically crosslinking technique, using epichlorohydrin as crosslinking agent. In both research studies, the amount of CS content in composition seemed to be essential to swelling capability of the matrix.…”

Section: Chondroitin Sulfate Hydrogelsmentioning

confidence: 99%

The Role of Anionic Polysaccharides in the Preparation of Nanomedicines with Anticancer Applications

Martı́nez

Benito²,

Pérez³

et al. 2016

CPD

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Cancer has become one of the main causes of death in developed countries, and it is expected to be declared as the disease with the highest worldwide morbidity and mortality indexes in the coming decades. Nanomedicine aims to overcome some problems related to this prevalent disease, particularly the lack of efficient diagnostic and therapeutic tools. The most recent scientific advances, which have conducted to a more personalized medicine, were focused on the production of nanocarriers involved into the transport and the delivery of drugs to targeted cells. A wide variety of nanocarriers composed by different materials have been designed for their use as drug delivery systems. Polysaccharides have emerged as very useful biopolymers among all raw materials used in the preparation of these nanoplatforms. They are highly stable, non-toxic and biodegradable molecules, and also present some chemical properties which are very difficult to reproduce using artificial polymers. Anionic polymers, such as hyaluronic acid, heparin or alginate, present some structural and chemical characteristics which make them ideal polymers to prepare nanosystems with anticancer applications. This review will focus on the description of some anionic polysaccharides and the possibilities they offer towards the preparation of nanosystems with applications in cancer treatment and diagnostics.

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Synthesis and characterization of some cellulose/chondroitin sulphate hydrogels and their evaluation as carriers for drug delivery

Cited by 35 publications

References 50 publications

Synthesis and characterization of polyvinyl alcohol/cellulose cryogels and their testing as carriers for a bioactive component

Synthesis and characterization of polyvinyl alcohol/cellulose cryogels and their testing as carriers for a bioactive component

Cellulose-Based Gels

The Role of Anionic Polysaccharides in the Preparation of Nanomedicines with Anticancer Applications

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