Synthesis and Characterization of Some New Tropylidene Derivatives and Studying their Biological Activities

Al-Abbasee, Muath Jabbar Tarfa; jebur, Ahmood khalaf; Shihab, Afraa Sabir

doi:10.24996/ijs.2021.62.9(si).2

Cited by 3 publications

(4 citation statements)

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“…12). Synthesis of 5-(4-bromophenyl)oxazol-2amine [16]: In flask of 100 mL [0.03 Mole, 3.78 gm] iodine; [0.006 Mole, 0.36 gm] urea and [0.003 Mole, 0.59 gm] bromoacetophenon were added. The mixture was heated for 8 hrs on a water bath, cooled and washed by diethyl ether and solution of sodium thiosulfate.…”

Section: )mentioning

confidence: 99%

“…Synthesis of [17]: 0.01 Mole, 3.14 gm] compound (16) was stirred in 30 mL of ethanol absolute then [0.01 Mole, 1.85 gm] of bromobenzaldehyde was added and the mixture has been refluxed for 6 hrs. Then cooled at room temperature by using appropriate solvent the precipitate was recrystallized after been filtered .…”

Section: )mentioning

confidence: 99%

“…The biological activity of any compound depends on its molecular structure where most of heterocyclic compounds contain sulfur atom do carry pharmaceutical activity and various medical applications [6][7][8][9][10][11][12]. The therapeutic effects of compounds contain 1,3,4-thiadiazole ring have well been studied for number of pathological states including antibacterial, antimycotic, antituberculer, anti-Parkinson cancer drug, anti-inflammatory and anticonvulsant [13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of some new heterocyclic derivatives from aromatic carbonyl compounds and assessment of their antimicrobial activity

2023

JPTCP

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This research work involves synthesis of 18 heterogeneous tetra, penta lateral cyclic compounds (1,3,1,2, Carbothioamide; Thiazole-4-one; Azetidin-2one; Oxazol) compounds. The thiazolidine-4-one was prepared by reaction of p-chlorobenzoic acid with thiosemicarbazide to yield the compound-1, which was treated with p-tolualdehyde to produce compound-2 followed by refluxing (2) with mercaptoacetic acid in dry benzene to yield thiazolidine-4-one compound (3). The reaction of p-nitro benzoic acid with ethanol in the presence of sulphonic acid yielded compound-4 and the reaction of ( 4) with thiosemicarbazide and 4% NaOH led to produce ring closure giving rise to 1,2,4-triazole (6). The thiosemicarbazone was prepared by the reaction of thiosemicarbazide with different aldehyde (7-9) compounds, A2-substituted -1,3-thiazolidine-4-one were synthesized by the reaction of thiosemicarbazone with chloroacetic acid in the presence of anhydrous sodium acetate yielded (10-12) compounds. The compound-15 was made by the reaction of p-amino benzoic acid with ethyl chloroacetate produced compound-13, then treated with urea to obtain the compound-14 followed by 4-phenyl phenacyl bromide to prepare compound-15. The 2azetidinone derivative was synthesized by many steps started from cyclization of p-bromoacetophenon with urea in iodine to yield compound-16 which was reacted with p-bromobenzaldehyde to yield compound-17. Schiff base has been treated with chloroacetyl chloride in the presence of catalytic amount of tri-ethyl amine to produce compound-18. All the synthesized compounds were characterized spectroscopically by both FT-IR spectroscopy and by H1-NMR, and C13-NMR for others. Almost all showed matching features and the validity of the proposed structure. The following synthesized compounds (2,3,6,11,13,15,17,18) were also tested against two types of bacteria (Staphylococcus aureus and Escherichia coli and fungus Candida albicans where they showed potential antibacterial and antifungal activities, respectively.

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Section: )mentioning

confidence: 99%

Section: )mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis of some new heterocyclic derivatives from aromatic carbonyl compounds and assessment of their antimicrobial activity

2023

JPTCP

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“…The common synthesis of thiadiazole requires the reaction of hydrazine with carbon disulfide (Losanitch, 1922), and also oxidation of Bithioureas by hydrogen peroxide (Guha, 1922). Thiadiazoles could be also prepared from the reaction of thiosemicarbazide with carbon disulfide in the presence of Na2CO3 (Al-Badrani et al, 2010). The synthesis of thiadiazole Schiff bases has also received a lot of interest because it is well-known that Schiff bases containing heterocyclic rings are cytotoxic and that they act against microorganisms and are anti-cancer and anti-fungal, malarial, viral, and bacterial infections.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Molecular Docking Studies of New Series of Bis-Schiff Bases Thiadiazoles Derived From Disulfides and Thioethers with Potent Antibacterial Properties

Hamad

Taher

Aziz

2022

SJUOZ

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Two new series of various heterocyclic bis-Schiff bases of Thiadiazoles disulfides and thioethers are synthesized. The first series was the synthesis of bis-Schiff of thiadiazole disulfides (4a-h) synthesized from their corresponding Schiff bases after oxidation by hydrogen peroxide. The second series was the synthesis of bis-Schiff base thiadiazole thioethers (7a-h). It was obtained from the reaction of bis-thiadiazole diamine (6) with different aldehyde. The diamine (6) was generated by reacting thiadiazole with dibromoethane in dimethylformamide and triethylamine as a catalyst. All of the synthesized compounds were analyzed by using FT-IR, 1H-NMR, 13C-NMR, and C-APT techniques. The synthesized compounds were screened against two gram-positive bacteria (Staphylococcus and streptococcus), and two strains of gram-negative (E. coli and klebsiella) in comparison to two standard strong antibiotic drugs (ciprofloxacin and vancomycin). Generally, all the synthesized compounds showed highly antibacterial properties, particularly, compounds (4b,4f, and 7b) which observed potent anti-bacterial properties against both gram- (positive, negative) bacteria were even higher than the standard drugs. Lastly, molecular docking studies were also applied to find the binding affinity and active sides of the products with the target proteins.

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Metal (II) complexes derived from proline dithiocarbamate and ligand adducts phenathroline: Synthesis, characterization, biological activity and SEM study

Ahmed,

Mohammed

2024

Fifth International Conference on Applied Sciences: Icas2023

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Synthesis and Characterization of Some New Tropylidene Derivatives and Studying their Biological Activities

Cited by 3 publications

References 19 publications

Synthesis of some new heterocyclic derivatives from aromatic carbonyl compounds and assessment of their antimicrobial activity

Synthesis of some new heterocyclic derivatives from aromatic carbonyl compounds and assessment of their antimicrobial activity

Synthesis and Molecular Docking Studies of New Series of Bis-Schiff Bases Thiadiazoles Derived From Disulfides and Thioethers with Potent Antibacterial Properties

Metal (II) complexes derived from proline dithiocarbamate and ligand adducts phenathroline: Synthesis, characterization, biological activity and SEM study

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