Synthesis and Characterization of Silica Nanoparticles with Well-Defined Thermoresponsive PNIPAM via a Combination of RAFT and Click Chemistry

Chen, Jiucun; Liu, Mingzhu; Chen, Chen; Gong, Honghong; Gao, Chunmei

doi:10.1021/am2007189

Cited by 108 publications

(73 citation statements)

References 51 publications

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“…As shown in Figure 5(III)a, the main temperature regions of weight loss appear in the interval 400-500°C, which can be assigned to the dehydration condensation reaction of the hydroxyl on the silica surface , and the chemical reaction equations can be expressed as Equation (1) [48], the surface grafting density of SiO 2 -TDI and SiO 2 -P(7-6-AC)-b-PNIPAAm was calculated to be about 1.29 mmol/g (0.222 g/g) and 0.02 mmol/g (0.188 g/g) respectively. Obviously, the graft density obtained from 'click chemistry' is higher than that of the traditional and classic method [49,50], for example SiO 2 surface silanization using silane coupling agent.…”

Section: Fabrication Ofmentioning

confidence: 91%

Dual-switchable surfaces between hydrophobic and superhydrophobic fabricated by the combination of click chemistry and RAFT

Han¹,

Zhang²,

Li³

et al. 2014

Express Polym. Lett.

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The wetting properties of superhydrophobic surfaces have received worldwide and tremendous attention [1] since the dual hierarchical structure of the lotus leaf was discovered [2]. Lotus-Leaf-like superhydrophobic surfaces, exhibit an amazing property for not only being wetted by water leading to a self-cleaning effect [3], but also for their great advantages in applications. In recent years, superhydrophobic surfaces are widely used in the human body implant materials [4], microfluidic tools [5], Calix azacrown [6], tunable optical lenses [7], labon-chip systems [8]. The wettability of the surface is influenced by its chemical composition and morphology [9], because chemical composition determines the surface free energy, and a lower surface energy leads to higher hydrophobicity. Additionally, the hierarchical structure (micro roughness covered with nano roughness) was not only necessary for a high contact angle (CA) but essential for the stability of the water-solid and water-air interfaces [10] Received 1 January 2014; accepted in revised form 1 April 2014Abstract. A dual-switchable surface between hydrophobic and superhydrophobic has been fabricated successfully by combining reversible addition-fragmentation chain transfer polymerization (RAFT) polymeric technology and thiol-NCO click chemistry. Well-defined block copolymer, poly(7-(6-(acryloyloxy) hexyloxy) coumarin)-b-poly(N-Isopropylacryl amide), was synthesized by RAFT, and then the block copolymer was grafted onto the surface of SiO 2 modified by toluene disocynate (TDI) via thiol-NCO click chemistry. The results of nuclear magnetic resonance (NMR) and Fourier Transform Infrared (FTIR) spectroscopies confirmed that the block copolymer (Number average molecular weight (M n ) = 9400, polydispersity index (PDI) = 1.22) has been synthesized successfully. The static contact angle (CA) of the surface prepared by SiO 2 /P (7-6-AC)-b-PNIPAAm switches from 98±2 to 137±2° by adjusting the temperature. Furthermore, the contact angle can also oscillate between 137±2 and 157±2° on the irradiation of UV light at 365 and 254 nm, respectively. The dual-switchable surfaces exhibit high stability between hydrophilicity and superhydrophobicity. Therefore, the method provides a new method to fabricate the dual-stimuli-responsive surface with tunable wettability, reversible switching, and also be easily extended to other dual-responsive surfaces. This ability to control the wettability by the adjustment of the temperature and UV light has applications in a broad range of fields.

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Section: Fabrication Ofmentioning

confidence: 91%

Dual-switchable surfaces between hydrophobic and superhydrophobic fabricated by the combination of click chemistry and RAFT

Han¹,

Zhang²,

Li³

et al. 2014

Express Polym. Lett.

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“…The spectra of MPS functionalized particles (inset zoomed area) showed two peaks at 1704 and 1630 cm -1 due to carbonyl (C=O) and C=C stretching vibrations, respectively [27]. The copolymer-grafted particles (lower spectrum in inset zoomed area) showed peaks at 1702, 1668, 1551, 1460 cm -1 due to MPS carbonyl, secondary amide carbonyl, secondary amide -N-H bending and C-H asymmetric bending of the isopropyl group respectively [28,29]. TGA curves of the SBA-15, SBA-MPS and poly(NIPAM-co-AM)/SBA samples are shown in Figure 7.…”

Section: Characterization Ofmentioning

confidence: 98%

Thermoresponsive copolymer-grafted SBA-15 porous silica particles for temperature-triggered topical delivery systems

Jadhav¹,

Scalarone²,

Brunella³

et al. 2017

Express Polym. Lett.

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Abstract.A series of poly(N-isopropylacrylamide-co-acrylamide) thermoresponsive random copolymers with different molecular weights and composition were synthesized and characterized by attenuated total reflectance Fourier-transform infrared (ATR-FTIR), differential scanning calorimetry (DSC), size exclusion chromatography (SEC) and proton nuclear magnetic resonance (NMR) spectroscopy. The lower critical solution temperatures (LCST) of the copolymers were tuned by changing the mole ratios of monomers. Copolymer with highest molecular weight and LCST (41.2°C) was grafted on SBA-15 type mesoporous silica particles by a two-step polymer grafting procedure. Bare SBA-15 and the thermoresponsive copolymergrafted (hybrid) SBA-15 particles were fully characterized by scanning electron microscope (SEM), ATR-FTIR, thermogravimetric analysis (TGA) and Brunauer-Emmett-Teller (BET) analyses. The hybrid particles were tested for their efficiency as temperature-sensitive systems for dermal delivery of the antioxidant rutin (quercetin-3-O-rutinoside). Improved control over rutin release by hybrid particles was obtained which makes them attractive hybrid materials for drug delivery.

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“…Poly N-isopropyl acrylamide (PNIPAM) has been well known as a thermoresponsive polymer. As depicted in Figure 12, Chen et al 128 reported a thermo-responsive DDS synthesized by covalent functionalization of silica nanoparticles with PNIPAM by a combination of reversible addition-fragmentation chain transfer and click chemistry. The thermal-induced conformational changes of the NIPAM polymer layer on the exterior surface of the MSN could be used as a switch to control the cargo release.…”

Section: Thermo-responsive Drug Deliverymentioning

confidence: 99%

“…MSNs for stimuli-responsive controlled drug delivery 128 The expression of (i) and (ii) indicates the addition order of the reaction materials. Abbreviations: PNIPAM, poly N-isopropyl acrylamide; RAFT, reversible addition-fragmentation chain transfer; AIBN, azobisisobutyronitrile.…”

mentioning

confidence: 99%

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Song

et al. 2016

IJN

188

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Synthesis and Characterization of Silica Nanoparticles with Well-Defined Thermoresponsive PNIPAM via a Combination of RAFT and Click Chemistry

Cited by 108 publications

References 51 publications

Dual-switchable surfaces between hydrophobic and superhydrophobic fabricated by the combination of click chemistry and RAFT

Dual-switchable surfaces between hydrophobic and superhydrophobic fabricated by the combination of click chemistry and RAFT

Thermoresponsive copolymer-grafted SBA-15 porous silica particles for temperature-triggered topical delivery systems

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

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