Synthesis and Characterization of Side Group–Modified Cyclotetraphosphazene Derivatives

Abstract

Two novel cyclotetraphosphazene derivatives were synthesized by the reaction of octachlorocyclotetraphosphazene with the potassium salt of 4-hydroxybenzaldehyde, and subsequent reduction of aldehyde groups to alcohol groups using sodium borohydride. The bromination reaction was carried out using PBr 3 to give N 4 P 4 (OC 6 H 4 -p-CH 2 Br) 8 (4). This compound was employed in reaction with imidazole or morpholine to produce eight-armed, star-branched title compounds. The target compounds were characterized by 1 H, 31 P, and 13 C NMR as well as IR and ESI-MS. The Cu complex of 5a was effective in oxidative cleavage reactions.

2-Naphthylthio Cyclotriphosphazene Derivatives: Synthesis, Characterization, Crystallographic and Fluorescence Properties

“…The most well-known and studied derivatives of cyclophosphazenes are trimer (hexachlorocyclotriphosphazene) and tetramer (octachlorocyclotetraphosphazene). Thanks to their active phosphorus-chlorine bonds, they can be used with many different groups and easily give chlorine displacement reactions (10)(11)(12)(13)(14)(15)(16). Another reason these compounds are preferred is to be used as the starting material in the preparation of polyphosphazenes which is the largest class of known inorganic polymers (12).…”

“…Another reason these compounds are preferred is to be used as the starting material in the preparation of polyphosphazenes which is the largest class of known inorganic polymers (12). Also, they can be used as ligand in coordination chemistry and organometallic chemistry (10)(11)(12)(13)(14). Six-membered trimer (P3N3) is more preferred and studied than eight-membered tetramer (P4N4) because it is planar, stable, rigid, and its product range is less than tetramer (17)(18)(19)(20).…”

Phosphorus–nitrogen compounds: part 30. Syntheses and structural investigations, antimicrobial and cytotoxic activities and DNA interactions of vanillinato-substituted NN or NO spirocyclic monoferrocenyl cyclotriphosphazenes

“…In addition, aziridine-crown substituted cyclotriphosphazenes, known as the hazardous compounds, cleave the DNA and halt the growth of cancer cells [22]. Also, the Cu+2 complex of fully phenoxysubstituted cyclotetraphosphazene was found to be alive in the oxidative cleavage of DNA [23]. Due to the increasing prevalence of antibiotic-resistant pathogens in the hospital, critical researches are underway for alternative treatments and alternative medicines [24].…”

Phosphorus–nitrogen compounds: Part 31. Syntheses, structural and stereogenic properties, in vitro cytotoxic and antimicrobial activities, and DNA interactions of bicyclotetraphosphazenes containing bulky side group

“…It is known that octapyrrolidinocyclotetraphosphazene demonstrates significant anticancer activity [15]. The Cu(II) complex of a fully phenoxy-substituted star-branched cyclotetraphosphazene is active in the oxidative cleavage of DNA [19].…”