Synthesis and Characterization of Ruthenium and Rhenium Nucleosides

Abstract

We report the synthesis and characterization of new ruthenium and rhenium nucleosides [Ru(tolyl-acac) 2 (IMPy)-T] (tolyl-acac ) di(p-methylbenzonatemethane), IMPy ) 2′-iminomethylpyridine, T ) thymidine) ( 5) and [Re(CO) 3 -(IMPy)-T]Cl (9), respectively. Structural analysis of 9 shows that the incorporation of this metal complex causes minimal perturbation to the sugar backbone and the nucleobase. Eletrochemical (5, E 1/2 ) 0.265 V vs NHE; 9, E 1/2 ) 1.67 V vs NHE), absorption (5, λ max ) 600, 486 nm; 9, λ max ) 388 nm), and emission (9, λ max ) 770 nm, π ) 17 ns) data indicate that 5 and 9 are suitable probes for DNA-mediated ground-state electron-transfer studies. The separation and characterization of diastereoisomers of 5 and bipyridyl-based ruthenium nucleoside [Ru(bpy) 2 -(IMPy)-T] 2+ (7) are reported.

Pyrazinamide drug interacting with Co(III) and Zn(II) metal ions based on 2,2′-bipyridine and 1,10-phenanthroline ligands: Synthesis, studies and crystal structure, DFT calculations and antibacterial assays

“…The cobalt-amide-N bond is markedly shorter than the cobalt-pyrazine-N bond (1.904 and 1.932 Å respectively). This is also observed in other complexes containing ligands 2-pyridinecarboxamides in their deprotonated form [49][50][51][52]. The average CAC bond length in the rings (PZAH 2 ) is 1.386 Å, which are very similar to the observed bonds in the free ligand (1.383 Å).…”

UHV-STM Investigations and Numerical Calculations of a Ruthenium β-Diketonato Complex with Protected Ethynyl Ligand: [Ru(dbm)2(acac-TIPSA)]

“…The Ru-O distances and the bond angles are consistent with the range of values reported for the same kind of systems. 43,52 Figure 2. ORTEP drawing of [Ru(dbm) 2 (acac-TIPSA)] 2 (30% of probability thermal ellipsoids)…”

Spectral signature of a Ru(ii, iii, iv) complex: a combined experimental and theoretical investigation

“…The computed distances are also in rather good agreement with the experimental ones previously reported in the literature for similar compounds. 14,15,[44][45][46][47][48][49][50][51] From a structural point of view, not surprisingly oxidation seems mainly to affect the Ru coordination sphere, following the expected contraction of the Ru-O bonds when one goes from Ru(II) S=0 to Ru(IV) S=1 , the average Ru-O bond length varying from 2.042 Å (computed for Ru(II)) to 1.986 Å (computed for Ru(IV)).…”