Synthesis and characterization of porous hybrid biomaterials with improved mechanical properties

Abstract

New ceramic-polymer biomaterials with controlled porosity were synthesized with improved mechanical and tribological properties. These materials contain synthetic hydroxyapatite (HAp) microparticles and two different ceramic particles at different concentrations (alumina microparticles and silica nanoparticles) and posses a morphology that matches the real bone. The particles were agglutinated using solvent-free, mono-component polyurethane. The pores were generated by a chemical reaction between the OH groups of the hydroxylated resin and the ceramic particles with the blocked isocyanate. The porosity grows practically linear with the temperature of the thermal treatment. The materials were characterized using X-ray diffraction (XRD), ICP, dynamic light scattering (DLS), scanning electron microscopy (SEM), densitometry, abrasion, and mechanical tests.

HAp/TiO2 nanocomposites: Influence of TiO2 on microstructure and mechanical properties

“…The sample with 75% alumina and 25% silica had obtained highest density (0.987 g/ ml). Estevez et al 21 synthesized a new ceramic-polymer biomaterial with controlled porosity with improved mechanical and tribological properties.…”

Effects of hydroxyapatite/collagen composite on osteogenic differentiation of rat bone marrow derived mesenchymal stem cells

“…The organic phase consists of 90% type I collagen (Col) fibers and the remaining 10% consists of various proteoglycans and other proteins. 14,15 Previously, many investigators attempted to model the natural matrix by producing materials containing HA and/or Col I and in vitro studies suggested that these matrices were usually highly osteoconductive. 16–18 More recently, some researches focused on the effects of HA and Col on the function of bone cells.…”