Synthesis and Characterization of Polyrotaxanes Comprising γ‐CDs and Distal Azide‐Terminated PHEMA Using Propargylamine Monosubstituted β‐CDs as End Stoppers

Abstract

To highlight whether γ‐cyclodextrins (CDs) facilitate propargylamine monosubstituted β‐CDs (PA‐β‐CDs) as end stoppers to get threaded onto a distal azide terminated poly(2‐hydroxyethylmethacrylate) (PHEMA) homopolymer (PH‐46‐2N3) to create linear and hyperbranched polyrotaxanes (PRs) via the in situ copper‐catalyzed azide/alkyne cycloaddition (CuAAC), PH‐46‐2N3 is self‐assembled with a varying amount of γ‐CDs in water and then subjected the CuAAC with PA‐β‐CDs to end‐cap the resulting γ‐CD‐PHEMA polypseudorotaxanes (PPRs) into the γ‐CD‐PHEMA PRs. It demonstrates that γ‐CDs cannot promote PA‐β‐CDs to be entrapped on the PHEMA chain most likely due to their different cavity size and molecular framework and linear PRs are always formed with up to 29% γ‐CD coverage ratio along the PHEMA axis thereof.

Synthesis of Poly(Methyl Methacrylate)-Based Polyrotaxane via Reversible Addition–Fragmentation Chain Transfer Polymerization

“…This result implies that γCD was threaded by the axis polymer so that the mobilities of two components were synchronized as the evidence of the presence of threaded γCD. From the 13 C CP/MAS result (see Figure S6), the peak at about 40 ppm is considered as another evidence for the rotaxanation in the PR according to a previous study . As a result, PR preparation via RAFT polymerization of inclusion complexes was proven to be possible.…”

“…From the 13 C CP/ MAS result (see Figure S6), the peak at about 40 ppm is considered as another evidence for the rotaxanation in the PR according to a previous study. 14 As a result, PR preparation via RAFT polymerization of inclusion complexes was proven to be possible.…”