Synthesis and characterization of polyoxometalates loaded starch nanocomplex and its antitumoral activity

Zhai, Fengying; Li, Dongliu; Zhang, Chunli; Wang, Xiaohong; Li, Rui

doi:10.1016/j.ejmech.2007.11.032

Cited by 40 publications

(24 citation statements)

References 9 publications

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“…An improvement in their physiological stability as well as biological activity can be achieved by appropriate modifications of their surface charge, polarity, redox potential, etc., by combining POMs with nano drug delivery carriers based on biodegradable polymers. Zhai et al have reported the use of a water-in-oil emulsion technique to prepare Si 2 W 18 Ti 6 polyoxometalate loaded starch nanoparticles with enhanced antitumor effects (Zhai, Li, Zhang, Wang, & Li, 2008).…”

Section: Introductionmentioning

confidence: 99%

A novel chitosan/polyoxometalate nano-complex for anti-cancer applications

Menon¹,

Thomas²,

Narayanan³

et al. 2011

Carbohydrate Polymers

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Section: Introductionmentioning

confidence: 99%

A novel chitosan/polyoxometalate nano-complex for anti-cancer applications

Menon¹,

Thomas²,

Narayanan³

et al. 2011

Carbohydrate Polymers

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“…POMs can be also regarded as oligomeric aggregates of metal cations bridged by oxide anions, which are formed by self-assembly processes. There are two generic families of POMs: the isopoly compounds (contain only the d0 metal cations and oxide anions) and the heteropoly compounds (that contain one or more p-, d-, or f-block "heteroatoms"in addition the other ions.In general, POMs belong to inorganic compounds with great molecular diversity in terms of shape, size, charge, polarity [2]. The diversity of POMs make them attractive for applications in medicine.…”

Section: Introductionmentioning

confidence: 99%

In vitro study on the antitumor activity of several new polyoxometalates

Zhao

Chuanhua

Dong

et al. 2011

Proceedings 2011 International Conference on Human Health and Biomedical Engineering

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Polyoxometalates ( POMs ) are negatively charged clusters consisting of transition metals and oxygen atoms. There are two general types of POM activity, antiviral and antitumoral, have dominated the medicinal chemistry of these compounds. Based on synthesized four different kind of POMs, [Ce(H 2 O) 7 Cr(OH) 6 Mo 6 O 18 ] n ·4nH 2 O, [Sm(H 2 O) 7 Cr(OH) 6 Mo 6 O 18 ] n ·4nH 2 O, Eu(H 2 O) 7 Cr(OH) 6-Mo 6 O 18 ] n ·4nH 2 O, and K 6 [P 2 W 18 O 62 ]·14H 2 O, we investigate their antitumor effect in vitro. K 6 [P 2 W 18 O 62 ]·14H 2 O exerted the most strong activity. IC 50 of it for MCF-7, SKOV-3 and HepG2 were 22 mol/L,19 mol/L and 24 mol/L respectively. Lower concentration of K 6 [P 2 W 18 O 62 ]·14H 2 O could induce HepG2 cells apoptosis . It up-regulated the expression of Bax and Bim , apoptosis promoting members in Bcl-2 family,so the mechanism of this effect may through mitochondria path way.

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“…[11][12][13] However, till now, most of the studies on the anticancer aspects of POMs still focus on the design and screening of potent POMs, as well as their pharmacology study, while a very limited effort has been devoted to the development of novel drug delivery systems for POMs. [14,15] Wang's group synthesized POM-loaded starch nanoparticles, which exhibited higher stability and antitumoral activity than free drugs, illustrating the desirable pharmacological activity of POM delivery systems. However, they used a water-in-oil emulsion process to prepare the POM-loaded nanoparticles, which required significant amounts of surfactant as well as a large amount of harmful organic solvent.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antitumoral Activity of Gelatin/Polyoxometalate Hybrid Nanoparticles

Guo

Cheng

et al. 2011

Macromolecular Bioscience

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Surfactant-free gelatin/heptamolybdate (HM) hybrid nanoparticles are prepared by a simple and environmentally friendly approach utilizing the electrostatic interaction between anionic HM and the zwitterionic gelatin. The obtained nanoparticles have a tunable size and very high HM loading content up to about 70%. In vitro and in vivo experiments prove that the gelatin/HM hybrid nanoparticles exhibit significantly better antitumor activity than plain ammonium heptamolybdate solution. Therefore, the gelatin/HM hybrid nanoparticles reported here may serve as a prototype platform for polymer/polyoxometalate (POM) hybrid nanoparticles as cancer treatment agents and hence open up more opportunities to maximize the potential of POM-based pharmaceutical agents.

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Synthesis and characterization of polyoxometalates loaded starch nanocomplex and its antitumoral activity

Cited by 40 publications

References 9 publications

A novel chitosan/polyoxometalate nano-complex for anti-cancer applications

A novel chitosan/polyoxometalate nano-complex for anti-cancer applications

In vitro study on the antitumor activity of several new polyoxometalates

Synthesis and Antitumoral Activity of Gelatin/Polyoxometalate Hybrid Nanoparticles

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