Synthesis and characterization of polyelectrolyte complex microparticles for drug release

Abstract

Free radical copolymerization of acryloxyethyl–trimethylammonium chloride with 2–hydroxyethyl methacrylate using sodium persulfate as initiator was carried out at 60°C and of its electrostatic interaction with sodium alginate (NaAlg) allowed obtaining polymeric microparticles by complex coacervation. The solute transport in this swellable matrix was investigated to check the effect of cross‐linking and simulated physiological condition over release process. Cefazolin Sodium loaded microparticles were prepared by incorporation of drug directly in the reaction mixture and their ability of releasing resulted in more extensive in enzyme‐free simulated intestinal medium. The polymeric microparticles prepared in this study were characterized by scanning electron microscopy showing irregular spherical form and rough structure. Particles showed unimodal distribution and the size distribution ranged from 1.1 to 1.8 mm (n = 100). © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

Preparation and characterization of pH‐sensitive microparticles based on polyelectrolyte complexes for antibiotic delivery

“…It can be seen that unloaded microparticles exhibited an irregular spherical shape with several wrinkles on their surface. Microparticles of similar appearance have been reported [42,43]. In the case of Cefotaxime-loaded microparticles change in the external morphology could be observed, showing more rough in comparison to unloaded poly(Q-co-VP)-1/AlgNa.…”

pH‐sensitive polyelectrolyte films derived from submicron chitosan/Eudragit® L 100‐55 complexes: Physicochemical characterization and in vitro drug release

“…Ionic interactions between oppositely charged polymers in aqueous solutions lead to the formation of nonpermanent and stimuli‐sensitive entities which are known as polyelectrolyte complexes (PECs) . Owing to their biodegradability and pH sensitivity, PECs are widely investigated as potential drug carriers in a various forms such as films, nanoparticles, microparticles, micelles, gels, and so on …”