Synthesis and characterization of poly(HEMA-co-EGDMA-co-VBC) by modified suspension polymerization: effects of polymerization parameters reaction on chemical and thermal properties of polymer

Norhayati, Abdullah; Zuhaili, Yahya Mohammad; Rabiatuladawiah, M.

doi:10.1016/j.matpr.2018.07.062

Cited by 8 publications

(5 citation statements)

References 22 publications

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“…The initial thermal decomposition occurred at a temperature range between 40 and 110 °C, due to the evaporation of the absorbed SBF in the matrix; then the gradual thermal decomposition was between 110 and 350 °C; this might be indicating the thermal decomposition of some low‐molecular‐weight impurities, such as uncrosslinked linear polymers. The terminal thermal decomposition occurred at the range between 350 and 600 °C, which was mainly attributed to the thermal decomposition of the bulk skeleton and also the P(MMA‐AA) with the crosslinking agent 31,32. Due to the decomposition of rigid structure, PMMA bone cement existed apparent thermal decomposition from 300 to 450 °C.…”

Section: Resultsmentioning

confidence: 99%

HEMA‐Modified Expandable P(MMA‐AA) Bone Cement with Dual Water Absorption Networks

Chen

Tang

Zhao

et al. 2020

Macro Materials & Eng

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Although the shrinkage of polymethyl methacrylate (PMMA) bone cement has been tackled by the poly(methyl methacrylate‐co‐acrylic acid) [P(MMA‐AA)] bone cement due to the expandable P(MMA‐AA) copolymer in the solid phase, the hydrophobicity of PMMA and its solidification restrict simulated body fluid (SBF) diffusion and expansion properties. In this research, hydroxyethyl methacrylate (HEMA)‐modified P(MMA‐AA) bone cement (HMBC) is obtained by introducing HEMA into the liquid phase of P(MMA‐AA) bone cement. It is assumed that the dual water absorption networks can promote the SBF absorption capacity, thus resulting in the increased expansion behavior. The results demonstrate that the introduction of HEMA improves the hydrophilicity of the bulk. SBF absorption efficiency and swelling efficiency are promoted in the primary step of expansion. The porous structure of HMBC contributes to the increased SBF absorption and swelling in the second step of expansion behavior. Meanwhile, the remarkable absorption ratio and expansion ratio reach 88.5% and 97.4%, respectively. Furthermore, enhanced biocompatibility and osteogenesis activity provide HMBC as a promising biomaterial in the clinical setting.

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Section: Resultsmentioning

confidence: 99%

HEMA‐Modified Expandable P(MMA‐AA) Bone Cement with Dual Water Absorption Networks

Chen

Tang

Zhao

et al. 2020

Macro Materials & Eng

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“…Hence, in the case of porosity analysis, we may conclude that low specific surface area of HP7 was due to the chemical reactions during hypercrosslinking that disrupted the wall of the pores and thus resulted to high mean pore size (447 nm). The presence of a stabilizer such as polyvinyl alcohol (PVA) or poly(N-vinylpyrrolidone) (PVP) in synthesizing EGDMA-based polymer plays a big role in producing well-defined spherical particles (beads) [24,44] with high porosity polymer microspheres [16,18]. The stabilizers hinder the coalescence of monomer droplets and then stabilize the polymer beads that have a tendency to agglomerate [45].…”

Section: Physiochemical Characterizationmentioning

confidence: 99%

Preparation of Ethylene Glycol Dimethacrylate (EGDMA)-Based Terpolymer as Potential Sorbents for Pharmaceuticals Adsorption

et al. 2020

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Ethylene glycol dimethacrylate (EGDMA) is used as a crosslinker in poly(acrylonitrile (AN)-co-vinylbenzyl chloride (VBC)) to investigate the effect of long-chain crosslinker to the porosity of the terpolymer system. Poly(AN-co-EGDMA-co-VBC) is synthesized by using precipitation polymerization method and further hypercrosslinked by Friedel-Crafts reaction. FT-IR spectra of poly(AN-co-EGDMA-co-VBC) show that the absorption bands at ~1290 cm−1 that are assigned to the C–Cl vibrations are almost disappeared in hypercrosslinked (HXL) poly(AN-co-EGDMA-co-VBC) polymers, confirming that the hypercrosslinking reaction is successful. SEM images show that the morphologies of the polymers are retained through the hypercrosslinking reactions. Brunauer–Emmett–Teller (BET) analysis shows that hypercrosslinked polymers had a specific surface area up to 59 m2·g−1. The preliminary performance of the terpolymer adsorbent to capture polar analyte is evaluated by adsorbing salicylic acid and mefenamic acid from aqueous solution in a batch system. The maximum adsorption capacity of salicylic acid and mefenamic acid were up to 416.7 mg·g−1 and 625 mg·g−1, respectively, and the adsorption kinetic data obeyed pseudo-second-order rate equation.

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“…Poly(HEMA-EGDMA-4-vinylbenzyl chloride) particles were obtained by suspension copolymerization of HEMA, EGDMA and 4-vinylbenzyl chloride in the presence of toluene, which was added to the polymerization composition to create a porous structure of the synthesized particles 58 . Polymer particles with a size of 150−350 μm were obtained by this method.…”

Section: Polyhema-based Drug Carriersmentioning

confidence: 99%

Hydrogels in Biomedicine: Granular Controlled Release Systems Based on 2-Hydroxyethyl Methacrylate Copolymers. A Review

Semenyuk,

Dudok,

Skorokhoda

2024

ChChT

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The article analyzes and summarizes the latest achievements in the field of polymer systems for controlled release devices based on hydrogel materials. Possible directions of drug delivery are presented, including the use of granular hydrogels, which work on the principle of drug sorption − release in the body. The research on the synthesis regularities, structure, properties, and prospects for the use of granular hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and its copolymers, in particular with polyvinylpyrrolidone (PVP), as systems for the controlled release of substances, in particular, drugs, is analyzed.

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Synthesis and characterization of poly(HEMA-co-EGDMA-co-VBC) by modified suspension polymerization: effects of polymerization parameters reaction on chemical and thermal properties of polymer

Cited by 8 publications

References 22 publications

HEMA‐Modified Expandable P(MMA‐AA) Bone Cement with Dual Water Absorption Networks

HEMA‐Modified Expandable P(MMA‐AA) Bone Cement with Dual Water Absorption Networks

Preparation of Ethylene Glycol Dimethacrylate (EGDMA)-Based Terpolymer as Potential Sorbents for Pharmaceuticals Adsorption

Hydrogels in Biomedicine: Granular Controlled Release Systems Based on 2-Hydroxyethyl Methacrylate Copolymers. A Review

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