Synthesis and characterization of poly(ethyl-2-cyanoacrylate) nanoparticles with a magnetic core

Optimization of maghemite-loaded PLGA nanospheres for biomedical applications

“…with a magnetic core as a useful tool for qualitatively checking the efficiency of the magnetite coating by the polymer. 39 For this purpose, the zeta potential of empty PLGA nanospheres, MagPLGA nanospheres and pure maghemite was assessed as a function of pH in the presence of 0.3 mM KCl. Figure 9 summarized these results.…”

From polymeric particles to multifunctional nanocapsules for biomedical applications using the miniemulsion process

“…The incorporated magnetite offers an easy and reliable assay for quantification of the internalized nanoparticles by generating Prussian blue. In an emulsion polymerization process, Arias et al 130 synthesized magnetite-poly(ethyl 2-cyanoacrylate) nanoparticles having an average size of 145 nm by covering magnetite with a shell of polymer.…”

Formulation of Fe3O4/Acrylate Co-Polymer Nanocomposites as Potential Drug Carriers

“…Besides the benefits of dosage reduction and minimizing systematic effects, a major advantage of magnetic drug targeting over conventional controlled release formulations is the possibility to turn off drug delivery rapidly by simply removing the external magnetic field. The nanosized particles are quickly transported to and excreted through kidney, which reduces the risk of drug build-up over time (Arias et al 2001;Yadav and Clayton 2005;Gupta and Gupta 2005).…”

“…Without further formulation, magnetic nanoparticles alone are reported to be ineffective drug carriers due to limitations in drug loading, release rates and retention time in the bloodstream (Arias et al 2001;Storm et al 1995). To overcome such difficulties, nanocomposites are synthesized by coating or encapsulating the nanosized magnetic particles with biocompatible materials.…”

“…To overcome such difficulties, nanocomposites are synthesized by coating or encapsulating the nanosized magnetic particles with biocompatible materials. In recent years, various groups have attempted to formulate magnetite-based nanocomposite particles using different shell materials: polyvinyl alcohol (Schulze et al 2005), folic acid-polyethylene glycol (PEG) (Zhang et al 2002;Gupta and Curtis 2004), starch (Alexiou et al 2000), poly(DL-lactide) , O-carboxymethylated chitosan (Zhao et al 2005) and poly(ethyl-2-cyanoacrylate) (Arias et al 2001). Other than Alexiou et al (2000) who found that drug release from the nanocomposites was dependent on blood electrolyte concentration, there are few other reports on the feasibility of drug loading and in vitro release from these formulations.…”