Synthesis and characterization of poly(antioxidant β-amino esters) for controlled release of polyphenolic antioxidants

Wattamwar, Paritosh P.; Biswal, Dibyajyoti; Cochran, David B.; Lyvers, Adam C.; Eitel, Richard E.; Anderson, Kimberly W.; Hilt, J. Zach; Dziubla, Thomas D.

doi:10.1016/j.actbio.2012.03.022

Cited by 50 publications

(58 citation statements)

References 31 publications

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“…composed of an apigenin based polymer, using a non-free radical-based polymerization scheme described for polyphenolic compounds. 16,18 These nanoparticles can theoretically be targeted to the vasculature, thereby providing a means of selective and long-term release. 26 Based upon prior work with cell adhesion molecule targeting of nanoparticles, it is expected that targeted particles injected would either bind to the vasculature or be rapidly cleared by the liver and spleen.…”

Section: Discussionmentioning

confidence: 99%

“…This chemistry allows for incorporation of flavonoids into the backbone of the polymer, creating a tunable release system while additionally protecting the active groups on flavonoids from premature oxidation. 16 As the polymer degrades, the active form of apigenin is released. Additionally, by developing a nanoparticle encapsulation delivery method, based on the biodegradable diblock copolymers methyoxypoly(ethylene glycol)-poly(lactide) (mPEG-PLA), both apigenin and apigenin PbAE polymers demonstrate slower release and high activity of active apigenin that can potentially overcome the limits presented by poor solubility and stability, and potentially provide a long-term delivery system.…”

Section: Introductionmentioning

confidence: 99%

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Degradable poly(apigenin) polymer inhibits tumor cell adhesion to vascular endothelial cells

et al. 2015

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Cancer and the inflammatory system share a complex intertwined relationship. For instance, in response to an injury or stress, vascular endothelial cells will express cell adhesion molecules as a means of recruiting leukocytes. However, circulating tumor cells (CTCs) have been shown to highjack this expression for the adhesion and invasion during the metastatic cascade. As such, the initiation of endothelial cell inflammation, either by surgical procedures (cancer resection) or chemotherapy can inadvertently increase the metastatic potential of CTCs. Yet, systemic delivery of anti-inflammatories, which weaken the entire immune system, may not be preferred in some treatment settings. In this work, we demonstrate that a long-term releasing flavone-based polymer and subsequent nanoparticle delivery system can inhibit tumor cell adhesion, through the suppression of endothelial cell adhesion molecule expression. The degradation of a this anti-inflammatory polymer provides longer term, localized release profile of active therapeutic drug in nanoparticle form as compared with that of the free drug, permitting more targeted anti-metastatic therapies. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1438-1447, 2016.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Degradable poly(apigenin) polymer inhibits tumor cell adhesion to vascular endothelial cells

et al. 2015

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“…20 An important difference from the curcumin release study was that the drug was previously added during PBAE macromer synthesis, which allowed it to covalently bind with the diacrylate. 45 This process helped prevent premature release or diffusion of drug from the gel matrix prior to hydrolysis, providing greater control over curcumin release. 45 Instead of being covalently incorporated during macromer synthesis, the macromer was polymerized around the protein in the present studies.…”

Section: Discussionmentioning

confidence: 99%

“…45 This process helped prevent premature release or diffusion of drug from the gel matrix prior to hydrolysis, providing greater control over curcumin release. 45 Instead of being covalently incorporated during macromer synthesis, the macromer was polymerized around the protein in the present studies. Because lysozyme is a much larger molecule, the protein could be entrapped in the polymer mesh structure.…”

Section: Discussionmentioning

confidence: 99%

Drug release from calcium sulfate-based composites

Orellana

Hilt

Puleo

2014

J. Biomed. Mater. Res.

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To help reduce the need for autografts, calcium sulfate-based bone graft substitutes are being developed to provide a stable platform to aid augmentation while having the ability to release a broad range of bioactive agents. Calcium sulfate (CS) has an excellent reputation as a biocompatible and osteoconductive substance, but addition of bioactive agents may further enhance these properties. Samples were produced with either directly loaded small, hydrophobic molecule (i.e., simvastatin), directly loaded hydrophilic protein (i.e., lysozyme), or 1 and 10 wt% of H6 poly(β-amino ester) (PBAE) particles containing protein. Whereas sustained release of directly loaded simvastatin was achieved, direct loading of small amounts of lysozyme resulted in highly variable release. Direct loading of a larger amount of protein generated a large burst, 65% of total loading, followed by sustained release of protein. Release of lysozyme from 1 wt% PBAE particles embedded into CS was more controllable than when directly loaded, and for 10 wt% of protein-loaded PBAE particles, a higher burst was followed by sustained release, comparable to the results for the high direct loading. Compression testing determined that incorporation of directly loaded drug or drug-loaded PBAE particles weakened CS. In particular, PBAE particles had a significant effect on the strength of the composites, with a 25% and 80% decrease in strength for 1 wt% and 10 wt% particle loadings, respectively. CS-based composites demonstrated the ability to sustainably release both macromolecules and small molecules, supporting the potential for these materials to release a range of therapeutic agents.

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“…Recently, much attention is being given to biomaterial-induced inflammatory response, which is inextricably linked to cellular oxidative stress, where cellular antioxidant defense mechanisms are overwhelmed by excessive generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) [31]. 2 ,7 -Dichlorodihydrofluorescein diacetate (DCFH-DA) is commonly used as a marker of oxidative stress in cells [75].…”

Section: Biocompatibility and Cytotoxicity Of Pnpsmentioning

confidence: 99%